SPRTN protease-cleaved MRE11 decreases DNA repair and radiosensitises cancer cells

The human MRE11/RAD50/NBS1 (MRN) complex plays a crucial role in sensing and repairing DNA DSB. MRE11 possesses dual 3’-5’ exonuclease and endonuclease activity and forms the core of the multifunctional MRN complex. We previously identified a C-terminally truncated form of MRE11 (TR-MRE11) associa...

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Bibliografiska uppgifter
Huvudupphovsmän: Na, J, Newman, J, Then, CK, Syed, J, Vendrell, I, Torrecilla, I, Ellermann, S, Ramadan, K, Fischer, R, Kiltie, A
Materialtyp: Journal article
Språk:English
Publicerad: Springer Nature 2021