The association of Plk1 with the astrin–kinastrin complex promotes formation and maintenance of a metaphase plate
Errors in mitotic chromosome segregation can lead to DNA damage and aneuploidy, both hallmarks of cancer. To achieve synchronous error-free segregation, mitotic chromosomes must align at the metaphase plate with stable amphitelic attachments to microtubules emanating from opposing spindle poles. The...
Main Authors: | Geraghty, Z, Barnard, C, Pelin, U, Gruneberg, U |
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Format: | Journal article |
Language: | English |
Published: |
Company of Biologists
2021
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