NMDA receptor blockers facilitate and impair learning via different mechanisms.
The NMDA receptor blockers CGP 37849 (competitive) and MK 801 (noncompetitive) improve retention performance in the step-down passive avoidance situation but impair it in the step-through dark avoidance. It is suggested that the drugs in the two tasks act on different underlying processes. Whereas t...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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1993
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| _version_ | 1797104689479680000 |
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| author | Mondadori, C Weiskrantz, L |
| author_facet | Mondadori, C Weiskrantz, L |
| author_sort | Mondadori, C |
| collection | OXFORD |
| description | The NMDA receptor blockers CGP 37849 (competitive) and MK 801 (noncompetitive) improve retention performance in the step-down passive avoidance situation but impair it in the step-through dark avoidance. It is suggested that the drugs in the two tasks act on different underlying processes. Whereas the memory facilitating effects of both drugs can be suppressed by pretreatment with either aldosterone or corticosterone, their negative effects on retention were steroid-insensitive. This set of results suggests that the mechanisms by which NMDA blockers improve memory are different from the mechanisms by which they block memory. |
| first_indexed | 2024-03-07T06:37:06Z |
| format | Journal article |
| id | oxford-uuid:f8074f1b-9006-4f2d-901a-23d91127b0a4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:37:06Z |
| publishDate | 1993 |
| record_format | dspace |
| spelling | oxford-uuid:f8074f1b-9006-4f2d-901a-23d91127b0a42022-03-27T12:47:16ZNMDA receptor blockers facilitate and impair learning via different mechanisms.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f8074f1b-9006-4f2d-901a-23d91127b0a4EnglishSymplectic Elements at Oxford1993Mondadori, CWeiskrantz, LThe NMDA receptor blockers CGP 37849 (competitive) and MK 801 (noncompetitive) improve retention performance in the step-down passive avoidance situation but impair it in the step-through dark avoidance. It is suggested that the drugs in the two tasks act on different underlying processes. Whereas the memory facilitating effects of both drugs can be suppressed by pretreatment with either aldosterone or corticosterone, their negative effects on retention were steroid-insensitive. This set of results suggests that the mechanisms by which NMDA blockers improve memory are different from the mechanisms by which they block memory. |
| spellingShingle | Mondadori, C Weiskrantz, L NMDA receptor blockers facilitate and impair learning via different mechanisms. |
| title | NMDA receptor blockers facilitate and impair learning via different mechanisms. |
| title_full | NMDA receptor blockers facilitate and impair learning via different mechanisms. |
| title_fullStr | NMDA receptor blockers facilitate and impair learning via different mechanisms. |
| title_full_unstemmed | NMDA receptor blockers facilitate and impair learning via different mechanisms. |
| title_short | NMDA receptor blockers facilitate and impair learning via different mechanisms. |
| title_sort | nmda receptor blockers facilitate and impair learning via different mechanisms |
| work_keys_str_mv | AT mondadoric nmdareceptorblockersfacilitateandimpairlearningviadifferentmechanisms AT weiskrantzl nmdareceptorblockersfacilitateandimpairlearningviadifferentmechanisms |