NMDA receptor blockers facilitate and impair learning via different mechanisms.
The NMDA receptor blockers CGP 37849 (competitive) and MK 801 (noncompetitive) improve retention performance in the step-down passive avoidance situation but impair it in the step-through dark avoidance. It is suggested that the drugs in the two tasks act on different underlying processes. Whereas t...
Main Authors: | Mondadori, C, Weiskrantz, L |
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פורמט: | Journal article |
שפה: | English |
יצא לאור: |
1993
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פריטים דומים
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MK-801 can facilitate passive avoidance memory when retention is not present in control animals, and can fail to facilitate when it is present.
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Systemic NMDA receptor antagonist CGP-40116 does not impair memory acquisition but protects against NMDA neurotoxicity in rhesus monkeys.
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