Coupling photo-responsive transmembrane ion transport with transition metal catalysis
Artificial ion transporters have been explored both as tools for studying fundamental ion transport processes and as potential therapeutics for cancer and channelopathies. Here we demonstrate that synthetic transporters may also be used to regulate the transport of catalytic metal ions across lipid...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
American Chemical Society
2024
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| _version_ | 1811139444755922944 |
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| author | Chao, X Johnson, T Temian, M-C Docker, A Wallabregue, A Scott, A Conway, S Langton, M |
| author_facet | Chao, X Johnson, T Temian, M-C Docker, A Wallabregue, A Scott, A Conway, S Langton, M |
| author_sort | Chao, X |
| collection | OXFORD |
| description | Artificial ion transporters have been explored both as tools for studying fundamental ion transport processes and as potential therapeutics for cancer and channelopathies. Here we demonstrate that synthetic transporters may also be used to regulate the transport of catalytic metal ions across lipid membranes and thus control chemical reactivity inside lipid-bound compartments. We show that acyclic lipophilic pyridyltriazoles enable Pd(II) cations to be transported from the external aqueous phase across the lipid bilayer and into the interior of large unilamellar vesicles. In situ reduction generates Pd(0) species, which catalyze the generation of a fluorescent product. Photocaging the Pd(II) transporter allows for photoactivation of the transport process and hence photocontrol over the internal catalysis process. This work demonstrates that artificial transporters enable control over catalysis inside artificial cell-like systems, which could form the basis of biocompatible nanoreactors for applications such as drug synthesis and delivery or to mediate phototargeted catalyst delivery into cells. |
| first_indexed | 2024-03-07T08:22:27Z |
| format | Journal article |
| id | oxford-uuid:f815bb2f-4289-480c-931d-190e5486ea85 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-09-25T04:06:11Z |
| publishDate | 2024 |
| publisher | American Chemical Society |
| record_format | dspace |
| spelling | oxford-uuid:f815bb2f-4289-480c-931d-190e5486ea852024-05-24T16:43:22ZCoupling photo-responsive transmembrane ion transport with transition metal catalysisJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f815bb2f-4289-480c-931d-190e5486ea85EnglishSymplectic ElementsAmerican Chemical Society2024Chao, XJohnson, TTemian, M-CDocker, AWallabregue, AScott, AConway, SLangton, MArtificial ion transporters have been explored both as tools for studying fundamental ion transport processes and as potential therapeutics for cancer and channelopathies. Here we demonstrate that synthetic transporters may also be used to regulate the transport of catalytic metal ions across lipid membranes and thus control chemical reactivity inside lipid-bound compartments. We show that acyclic lipophilic pyridyltriazoles enable Pd(II) cations to be transported from the external aqueous phase across the lipid bilayer and into the interior of large unilamellar vesicles. In situ reduction generates Pd(0) species, which catalyze the generation of a fluorescent product. Photocaging the Pd(II) transporter allows for photoactivation of the transport process and hence photocontrol over the internal catalysis process. This work demonstrates that artificial transporters enable control over catalysis inside artificial cell-like systems, which could form the basis of biocompatible nanoreactors for applications such as drug synthesis and delivery or to mediate phototargeted catalyst delivery into cells. |
| spellingShingle | Chao, X Johnson, T Temian, M-C Docker, A Wallabregue, A Scott, A Conway, S Langton, M Coupling photo-responsive transmembrane ion transport with transition metal catalysis |
| title | Coupling photo-responsive transmembrane ion transport with transition metal catalysis |
| title_full | Coupling photo-responsive transmembrane ion transport with transition metal catalysis |
| title_fullStr | Coupling photo-responsive transmembrane ion transport with transition metal catalysis |
| title_full_unstemmed | Coupling photo-responsive transmembrane ion transport with transition metal catalysis |
| title_short | Coupling photo-responsive transmembrane ion transport with transition metal catalysis |
| title_sort | coupling photo responsive transmembrane ion transport with transition metal catalysis |
| work_keys_str_mv | AT chaox couplingphotoresponsivetransmembraneiontransportwithtransitionmetalcatalysis AT johnsont couplingphotoresponsivetransmembraneiontransportwithtransitionmetalcatalysis AT temianmc couplingphotoresponsivetransmembraneiontransportwithtransitionmetalcatalysis AT dockera couplingphotoresponsivetransmembraneiontransportwithtransitionmetalcatalysis AT wallabreguea couplingphotoresponsivetransmembraneiontransportwithtransitionmetalcatalysis AT scotta couplingphotoresponsivetransmembraneiontransportwithtransitionmetalcatalysis AT conways couplingphotoresponsivetransmembraneiontransportwithtransitionmetalcatalysis AT langtonm couplingphotoresponsivetransmembraneiontransportwithtransitionmetalcatalysis |