Family history of cancer and risk of pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan).
A family history of pancreatic cancer has consistently been associated with increased risk of pancreatic cancer. However, uncertainty remains about the strength of this association. Results from previous studies suggest a family history of select cancers (i.e., ovarian, breast and colorectal) could...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2010
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| _version_ | 1826305734741065728 |
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| author | Jacobs, E Chanock, S Fuchs, C Lacroix, A McWilliams, R Steplowski, E Stolzenberg-Solomon, R Arslan, A Bueno-de-Mesquita, H Gross, M Helzlsouer, K Petersen, G Zheng, W Agalliu, I Allen, N Amundadottir, L Boutron-Ruault, M Buring, J Canzian, F Clipp, S Dorronsoro, M Gaziano, J Giovannucci, E Hankinson, SE Hartge, P |
| author_facet | Jacobs, E Chanock, S Fuchs, C Lacroix, A McWilliams, R Steplowski, E Stolzenberg-Solomon, R Arslan, A Bueno-de-Mesquita, H Gross, M Helzlsouer, K Petersen, G Zheng, W Agalliu, I Allen, N Amundadottir, L Boutron-Ruault, M Buring, J Canzian, F Clipp, S Dorronsoro, M Gaziano, J Giovannucci, E Hankinson, SE Hartge, P |
| author_sort | Jacobs, E |
| collection | OXFORD |
| description | A family history of pancreatic cancer has consistently been associated with increased risk of pancreatic cancer. However, uncertainty remains about the strength of this association. Results from previous studies suggest a family history of select cancers (i.e., ovarian, breast and colorectal) could also be associated, although not as strongly, with increased risk of pancreatic cancer. We examined the association between a family history of 5 types of cancer (pancreas, prostate, ovarian, breast and colorectal) and risk of pancreatic cancer using data from a collaborative nested case-control study conducted by the Pancreatic Cancer Cohort Consortium. Cases and controls were from cohort studies from the United States, Europe and China, and a case-control study from the Mayo Clinic. Analyses of family history of pancreatic cancer included 1,183 cases and 1,205 controls. A family history of pancreatic cancer in a parent, sibling or child was associated with increased risk of pancreatic cancer [multivariate-adjusted odds ratios (ORs) = 1.76, 95% confidence interval (CI) = 1.19-2.61]. A family history of prostate cancer was also associated with increased risk (OR = 1.45, 95% CI = 1.12-1.89). There were no statistically significant associations with a family history of ovarian cancer (OR = 0.82, 95% CI = 0.52-1.31), breast cancer (OR = 1.21, 95% CI = 0.97-1.51) or colorectal cancer (OR = 1.17, 95% CI = 0.93-1.47). Our results confirm a moderate sized association between a family history of pancreatic cancer and risk of pancreatic cancer and also provide evidence for an association with a family history of prostate cancer worth further study. |
| first_indexed | 2024-03-07T06:37:20Z |
| format | Journal article |
| id | oxford-uuid:f818150a-3844-4345-9520-b4d2ada47fbd |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:37:20Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:f818150a-3844-4345-9520-b4d2ada47fbd2022-03-27T12:47:54ZFamily history of cancer and risk of pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan).Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f818150a-3844-4345-9520-b4d2ada47fbdEnglishSymplectic Elements at Oxford2010Jacobs, EChanock, SFuchs, CLacroix, AMcWilliams, RSteplowski, EStolzenberg-Solomon, RArslan, ABueno-de-Mesquita, HGross, MHelzlsouer, KPetersen, GZheng, WAgalliu, IAllen, NAmundadottir, LBoutron-Ruault, MBuring, JCanzian, FClipp, SDorronsoro, MGaziano, JGiovannucci, EHankinson, SEHartge, PA family history of pancreatic cancer has consistently been associated with increased risk of pancreatic cancer. However, uncertainty remains about the strength of this association. Results from previous studies suggest a family history of select cancers (i.e., ovarian, breast and colorectal) could also be associated, although not as strongly, with increased risk of pancreatic cancer. We examined the association between a family history of 5 types of cancer (pancreas, prostate, ovarian, breast and colorectal) and risk of pancreatic cancer using data from a collaborative nested case-control study conducted by the Pancreatic Cancer Cohort Consortium. Cases and controls were from cohort studies from the United States, Europe and China, and a case-control study from the Mayo Clinic. Analyses of family history of pancreatic cancer included 1,183 cases and 1,205 controls. A family history of pancreatic cancer in a parent, sibling or child was associated with increased risk of pancreatic cancer [multivariate-adjusted odds ratios (ORs) = 1.76, 95% confidence interval (CI) = 1.19-2.61]. A family history of prostate cancer was also associated with increased risk (OR = 1.45, 95% CI = 1.12-1.89). There were no statistically significant associations with a family history of ovarian cancer (OR = 0.82, 95% CI = 0.52-1.31), breast cancer (OR = 1.21, 95% CI = 0.97-1.51) or colorectal cancer (OR = 1.17, 95% CI = 0.93-1.47). Our results confirm a moderate sized association between a family history of pancreatic cancer and risk of pancreatic cancer and also provide evidence for an association with a family history of prostate cancer worth further study. |
| spellingShingle | Jacobs, E Chanock, S Fuchs, C Lacroix, A McWilliams, R Steplowski, E Stolzenberg-Solomon, R Arslan, A Bueno-de-Mesquita, H Gross, M Helzlsouer, K Petersen, G Zheng, W Agalliu, I Allen, N Amundadottir, L Boutron-Ruault, M Buring, J Canzian, F Clipp, S Dorronsoro, M Gaziano, J Giovannucci, E Hankinson, SE Hartge, P Family history of cancer and risk of pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan). |
| title | Family history of cancer and risk of pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan). |
| title_full | Family history of cancer and risk of pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan). |
| title_fullStr | Family history of cancer and risk of pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan). |
| title_full_unstemmed | Family history of cancer and risk of pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan). |
| title_short | Family history of cancer and risk of pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan). |
| title_sort | family history of cancer and risk of pancreatic cancer a pooled analysis from the pancreatic cancer cohort consortium panscan |
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