Iron homeostasis and its interaction with prolyl hydroxylases.

Iron homeostasis and its interaction with prolyl hydroxylases.

The ability of iron to accept or donate electrons, coupled with the ability of oxygen to act as an electron acceptor, renders both elements essential to normal cellular biology. However, these same chemical properties allow free iron in solution to generate toxic free radicals, particularly in combi...

Bibliografski detalji
Glavni autor:	Mole, D
Format:	Journal article
Jezik:	English
Izdano:	2010

Slični predmeti

Regulation of HIF: prolyl hydroxylases.
od: Stolze, I, i dr.
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Determination and comparison of specific activity of the HIF-prolyl hydroxylases.
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2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase.
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Prolyl hydroxylases and therapeutics.
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Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases.
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Substrate selectivity of prolyl hydroxylases
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Characterization of different isoforms of the HIF prolyl hydroxylase PHD1 generated by alternative initiation.
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Differential prolyl hydroxylation by six Physcomitrella prolyl-4 hydroxylases
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Tuning the transcriptional response to hypoxia by inhibiting HIF prolyl- and asparaginyl-hydroxylases
od: Chan, M, i dr.
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Structural and mechanistic studies on prolyl hydroxylases
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Inhibition of a viral prolyl hydroxylase
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Structural, functional and evolutionary studies on prolyl-hydroxylases
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Regnase-1 Maintains Iron Homeostasis via the Degradation of Transferrin Receptor 1 and Prolyl-Hydroxylase-Domain-Containing Protein 3 mRNAs
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Collagen Prolyl 4-Hydroxylase as a Therapeutic Target
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Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion.
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od: Knowles, H, i dr.
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2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2.
od: Mecinović, J, i dr.
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Hypoxia inducible factor prolyl hydroxylases in inflammatory bowel disease
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Prolyl-hydroxylase inhibitors reconstitute tumor blood vessels in mice
od: Shunji Nishide, i dr.
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An Arabidopsis Prolyl 4 Hydroxylase Is Involved in the Low Oxygen Response
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Inhibition of HIF-prolyl hydroxylases improves healing of intestinal anastomoses
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Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate.
od: McNeill, L, i dr.
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Discovery of neuroprotective agents that inhibit human prolyl hydroxylase PHD2
od: Richardson, NL, i dr.
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Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase, and is sensitive to off target inhibition by prolyl hydroxylase domain inhibitors that stabilise Hypoxia Inducible Factor
od: Kiriakidis, S, i dr.
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Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
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Molecular and Cellular Mechanisms of HIF Prolyl Hydroxylase inhibitors in Clinical Trials
od: Yeh, TL, i dr.
Izdano: (2017)

Hypoxia-inducible factor prolyl-hydroxylase: purification and assays of PHD2.
od: Hewitson, K, i dr.
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Tissue expression and functional insights into HIF prolyl hydroxylase domain enzymes
od: Wijeyekoon, JB
Izdano: (2013)

Neuroprotective Effect of HIF Prolyl Hydroxylase Inhibition in an In Vitro Hypoxia Model
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TAF1 SPLICING VARIANTS AND PROLYL HYDROXYLASE INHIBITORS IN HUNTINGTON’S DISEASE
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