Differential sensitivity of beta-cell and extrapancreatic K(ATP) channels to gliclazide.

AIMS/HYPOTHESIS: To investigate the tissue specificity of gliclazide for cloned beta-cell, cardiac and smooth muscle ATP-sensitive K-channels (K(ATP) channels). These channels share a common pore-forming subunit, Kir6.2, which associates with different sulphonylurea receptor isoforms (SUR1 in beta-c...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron: Gribble, F, Ashcroft, F
Fformat: Journal article
Iaith:English
Cyhoeddwyd: 1999