Differential sensitivity to the environment: Contribution of cognitive biases and genes to psychological wellbeing
Negative cognitive biases and genetic variation have been associated with risk of psychopathology in largely independent lines of research. Here, we discuss ways in which these dynamicfields of research might be fruitfully combined. We propose that gene by environment (G × E) interactions may be med...
| Egile Nagusiak: | , |
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| Formatua: | Journal article |
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Nature Publishing Group
2016
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| _version_ | 1826305821454106624 |
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| author | Fox, E Beevers, C |
| author_facet | Fox, E Beevers, C |
| author_sort | Fox, E |
| collection | OXFORD |
| description | Negative cognitive biases and genetic variation have been associated with risk of psychopathology in largely independent lines of research. Here, we discuss ways in which these dynamicfields of research might be fruitfully combined. We propose that gene by environment (G × E) interactions may be mediated by selective cognitive biases and that certain forms of genetic‘reactivity’ or ‘sensitivity’ may represent heightened sensitivity to the learning environment in a‘for better and for worse’ manner. To progress knowledge in thisfield, we recommend including assessments of cognitive processing biases; examining G × E interactions in ‘both’ negative and positive environments; experimentally manipulating the environment when possible; and moving beyond single-gene effects to assess polygenic sensitivity scores. We formulate a new methodological framework encapsulating cognitive and genetic factors in the development of both psychopathology and optimal wellbeing that holds long-term promise for the development of new personalized therapies. |
| first_indexed | 2024-03-07T06:38:40Z |
| format | Journal article |
| id | oxford-uuid:f886ccd7-0f22-4a3c-bfda-e89f7e0409cc |
| institution | University of Oxford |
| last_indexed | 2024-03-07T06:38:40Z |
| publishDate | 2016 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:f886ccd7-0f22-4a3c-bfda-e89f7e0409cc2022-03-27T12:50:58ZDifferential sensitivity to the environment: Contribution of cognitive biases and genes to psychological wellbeingJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f886ccd7-0f22-4a3c-bfda-e89f7e0409ccSymplectic Elements at OxfordNature Publishing Group2016Fox, EBeevers, CNegative cognitive biases and genetic variation have been associated with risk of psychopathology in largely independent lines of research. Here, we discuss ways in which these dynamicfields of research might be fruitfully combined. We propose that gene by environment (G × E) interactions may be mediated by selective cognitive biases and that certain forms of genetic‘reactivity’ or ‘sensitivity’ may represent heightened sensitivity to the learning environment in a‘for better and for worse’ manner. To progress knowledge in thisfield, we recommend including assessments of cognitive processing biases; examining G × E interactions in ‘both’ negative and positive environments; experimentally manipulating the environment when possible; and moving beyond single-gene effects to assess polygenic sensitivity scores. We formulate a new methodological framework encapsulating cognitive and genetic factors in the development of both psychopathology and optimal wellbeing that holds long-term promise for the development of new personalized therapies. |
| spellingShingle | Fox, E Beevers, C Differential sensitivity to the environment: Contribution of cognitive biases and genes to psychological wellbeing |
| title | Differential sensitivity to the environment: Contribution of cognitive biases and genes to psychological wellbeing |
| title_full | Differential sensitivity to the environment: Contribution of cognitive biases and genes to psychological wellbeing |
| title_fullStr | Differential sensitivity to the environment: Contribution of cognitive biases and genes to psychological wellbeing |
| title_full_unstemmed | Differential sensitivity to the environment: Contribution of cognitive biases and genes to psychological wellbeing |
| title_short | Differential sensitivity to the environment: Contribution of cognitive biases and genes to psychological wellbeing |
| title_sort | differential sensitivity to the environment contribution of cognitive biases and genes to psychological wellbeing |
| work_keys_str_mv | AT foxe differentialsensitivitytotheenvironmentcontributionofcognitivebiasesandgenestopsychologicalwellbeing AT beeversc differentialsensitivitytotheenvironmentcontributionofcognitivebiasesandgenestopsychologicalwellbeing |