NF-kappaB-inducing kinase is dispensable for activation of NF-kappaB in inflammatory settings but essential for lymphotoxin beta receptor activation of NF-kappaB in primary human fibroblasts.
The transcription factor NF-kappaB is of major importance in the biology of pro-inflammatory cytokines, such as TNF-alpha and IL-1alpha, and thereby is intimately involved in the process of inflammation. Understanding the mechanisms by which NF-kappaB is activated in response to inflammatory stimuli...
Những tác giả chính: | Smith, C, Andreakos, E, Crawley, J, Brennan, F, Feldmann, M, Foxwell, B |
---|---|
Định dạng: | Journal article |
Ngôn ngữ: | English |
Được phát hành: |
2001
|
Những quyển sách tương tự
-
Activation of NF-kappaB by the intracellular expression of NF-kappaB-inducing kinase acts as a powerful vaccine adjuvant.
Bằng: Andreakos, E, et al.
Được phát hành: (2006) -
VEGF expression in human macrophages is NF-kappaB-dependent: studies using adenoviruses expressing the endogenous NF-kappaB inhibitor IkappaBalpha and a kinase-defective form of the IkappaB kinase 2.
Bằng: Kiriakidis, S, et al.
Được phát hành: (2003) -
VEGF expression in human macrophages is NF-kappaB-dependent: studies using adenoviruses expressing the endogenous NF-kappaB inhibitor IkappaBalpha and a kinase-defective form of the IkappaB kinase 2.
Bằng: Kiriakidis, S, et al.
Được phát hành: (2003) -
Is NF-kappaB a useful therapeutic target in rheumatoid arthritis?
Bằng: Feldmann, M, et al.
Được phát hành: (2002) -
NF-kappaB mediates tumor necrosis factor alpha-induced expression of optineurin, a negative regulator of NF-kappaB.
Bằng: Cherukuri Sudhakar, et al.
Được phát hành: (2009-01-01)