Structural basis and specificity of human otubain 1-mediated deubiquitination.

Structural basis and specificity of human otubain 1-mediated deubiquitination.

OTUB (otubain) 1 is a human deubiquitinating enzyme that is implicated in mediating lymphocyte antigen responsiveness, but whose molecular function is generally not well defined. A structural analysis of OTUB1 shows differences in accessibility to the active site and in surface properties of the sub...

書目詳細資料
Main Authors:	Edelmann, M, Iphöfer, A, Akutsu, M, Altun, M, di Gleria, K, Kramer, H, Fiebiger, E, Dhe-Paganon, S, Kessler, B
格式:	Journal article
語言:	English
出版:	2009

相似書籍

Post-translational modification of the deubiquitinating enzyme otubain 1 modulates active RhoA levels and susceptibility to Yersinia invasion.
由: Edelmann, M, et al.
出版: (2010)

Biochemical characterization of a novel deubiquitinating enzyme otubain 1 and investigation into its role in Yersinia infection
由: Edelmann, M, et al.
出版: (2010)

The human otubain2-ubiquitin structure provides insights into the cleavage specificity of poly-ubiquitin-linkages
由: Altun, M, et al.
出版: (2015)

Otubains
由: Kessler, B
出版: (2013)

Fluorescence-based active site probes for profiling deubiquitinating enzymes.
由: McGouran, J, et al.
出版: (2012)

The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER
由: Ploegh, Hidde, et al.
出版: (2009)

Deubiquitinating enzyme specificity for ubiquitin chain topology profiled by di-ubiquitin activity probes.
由: McGouran, J, et al.
出版: (2013)

Profiling ubiquitin linkage specificities of deubiquitinating enzymes with branched ubiquitin isopeptide probes.
由: Iphöfer, A, et al.
出版: (2012)

PTMs in conversation: activity and function of deubiquitinating enzymes regulated via post-translational modifications.
由: Kessler, B, et al.
出版: (2011)

PTMs in Conversation: Activity and Function of Deubiquitinating Enzymes Regulated via Post-Translational Modifications
由: Kessler, B, et al.
出版: (2011)

Structural and Functional Basis of JAMM Deubiquitinating Enzymes in Disease
由: Xin Pan, et al.
出版: (2022-06-01)

Otubain 2 promotes muramyl dipeptide‐mediated anti‐colitogenic effects due to de‐ubiquitination of receptor interaction protein 2
由: Jochen Mattner
出版: (2024-10-01)

Deubiquitination complex platform: A plausible mechanism for regulating the substrate specificity of deubiquitinating enzymes
由: Yi-Zheng Fang, et al.
出版: (2023-07-01)

Molecular basis for recognition and deubiquitination of 40S ribosomes by Otu2
由: Ken Ikeuchi, et al.
出版: (2023-05-01)

Knockdown of otubain 2 inhibits liver cancer cell growth by suppressing NF‐κB signaling
由: Zhen‐Lin Gu, et al.
出版: (2020-06-01)

USP10 deubiquitinates Tau, mediating its aggregation
由: Zhen Wei, et al.
出版: (2022-08-01)

Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits.
由: Kessler, B, et al.
出版: (2001)

Partial otubain 1 deficiency compromises fetal well-being in allogeneic pregnancies despite no major changes in the dendritic cell and T cell compartment
由: Annika Stutz, et al.
出版: (2022-11-01)

The ubiquitin‐specific protease 5 mediated deubiquitination of LSH links metabolic regulation of ferroptosis to hepatocellular carcinoma progression
由: Bokang Yan, et al.
出版: (2023-08-01)

Ubiquitin and ubiquitin-like specific proteases targeted by infectious pathogens: Emerging patterns and molecular principles.
由: Edelmann, M, et al.
出版: (2008)

Comprehensive Landscape of Active Deubiquitinating Enzymes Profiled by Advanced Chemoproteomics
由: Adán Pinto-Fernández, et al.
出版: (2019-08-01)

Deubiquitinating Enzymes and Bone Remodeling
由: Yu-chen Guo, et al.
出版: (2018-01-01)

Recent Progress of Deubiquitinating Enzymes in Human and Plant Pathogenic Fungi
由: Weixiang Wang, et al.
出版: (2022-10-01)

FKBP family proteins : immunophilins with versatile biological functions
由: Kang, Cong Bao, et al.
出版: (2012)

Ankylosing spondylitis monocytes show upregulation of proteins involved in inflammation and the ubiquitin proteasome pathway.
由: Wright, C, et al.
出版: (2009)

OTUD4-mediated GSDME deubiquitination enhances radiosensitivity in nasopharyngeal carcinoma by inducing pyroptosis
由: Muping Di, et al.
出版: (2022-11-01)

Comprehensive Landscape of Active Deubiquitinating Enzymes Profiled by Advanced Chemoproteomics
由: Pinto-Fernández, A, et al.
出版: (2019)

Structural basis for defective membrane targeting of mutant enzyme in human VLCAD deficiency
由: Michelle S. Prew, et al.
出版: (2022-06-01)

Accelerating inhibitor discovery for deubiquitinating enzymes
由: Wai Cheung Chan, et al.
出版: (2023-02-01)

USP47-mediated deubiquitination and stabilization of YAP contributes to the progression of colorectal cancer
由: Beiqing Pan, et al.
出版: (2019-11-01)

Ubiquitin-specific protease 29 attenuates hepatic ischemia-reperfusion injury by mediating TGF-β-activated kinase 1 deubiquitination
由: Zhongbao Chen, et al.
出版: (2023-05-01)

A genomic and functional inventory of deubiquitinating enzymes.
由: Nijman, S, et al.
出版: (2005)

Operative ubiquitin-specific protease 22 deubiquitination confers a more invasive phenotype to cholangiocarcinoma
由: Tian, Y, et al.
出版: (2021)

Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family.
由: Borodovsky, A, et al.
出版: (2002)

Systematic analysis of the physiological importance of deubiquitinating enzymes.
由: Wei-Ling Tsou, et al.
出版: (2012-01-01)

The Roles of Deubiquitination in Age-related Diseases
由: XU Linhui, LI Pengfei, WU Miaomiao, KANG Lihua, JI Min, YU Ying, GUAN Huaijin
出版: (2025-03-01)

The Importance of Ubiquitination and Deubiquitination in Cellular Reprogramming
由: Bharathi Suresh, et al.
出版: (2016-01-01)

Histone Deubiquitination Assay in Nicotiana benthamiana
由: Shujing Liu, et al.
出版: (2018-03-01)

Deubiquitinating enzymes for targeted cancer therapy
由: Yue Li, et al.
出版: (2023-12-01)

Deubiquitinating enzyme USP10 promotes hepatocellular carcinoma metastasis through deubiquitinating and stabilizing Smad4 protein
由: Tao Yuan, et al.
出版: (2020-01-01)