Parent-child concordance in multiple sclerosis.
It is now recognized that susceptibility to multiple sclerosis (MS) is determined in part by genetic factors. The gene loci influencing MS susceptibility are largely unidentified. In an attempt to better understand the mode of transmission, parent-child concordance for MS was studied in two large, p...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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1991
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| _version_ | 1826305844741931008 |
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| author | Sadovnick, A Bulman, D Ebers, G |
| author_facet | Sadovnick, A Bulman, D Ebers, G |
| author_sort | Sadovnick, A |
| collection | OXFORD |
| description | It is now recognized that susceptibility to multiple sclerosis (MS) is determined in part by genetic factors. The gene loci influencing MS susceptibility are largely unidentified. In an attempt to better understand the mode of transmission, parent-child concordance for MS was studied in two large, population-based MS clinic populations. Among 75 parent-child pairs concordant for MS, we found 40 mother-daughter pairs, 13 mother-son pairs, 21 father-daughter pairs, and 1 father-son pair. Controlling for the known female preponderance in MS, the data show a paucity of father-son pairs. These data have implications for understanding the mechanisms of inheritance for MS susceptibility as well as for risk counseling in families of patients. |
| first_indexed | 2024-03-07T06:39:01Z |
| format | Journal article |
| id | oxford-uuid:f8a4e4f5-167e-45ff-8f66-366b24639f76 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:39:01Z |
| publishDate | 1991 |
| record_format | dspace |
| spelling | oxford-uuid:f8a4e4f5-167e-45ff-8f66-366b24639f762022-03-27T12:51:49ZParent-child concordance in multiple sclerosis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f8a4e4f5-167e-45ff-8f66-366b24639f76EnglishSymplectic Elements at Oxford1991Sadovnick, ABulman, DEbers, GIt is now recognized that susceptibility to multiple sclerosis (MS) is determined in part by genetic factors. The gene loci influencing MS susceptibility are largely unidentified. In an attempt to better understand the mode of transmission, parent-child concordance for MS was studied in two large, population-based MS clinic populations. Among 75 parent-child pairs concordant for MS, we found 40 mother-daughter pairs, 13 mother-son pairs, 21 father-daughter pairs, and 1 father-son pair. Controlling for the known female preponderance in MS, the data show a paucity of father-son pairs. These data have implications for understanding the mechanisms of inheritance for MS susceptibility as well as for risk counseling in families of patients. |
| spellingShingle | Sadovnick, A Bulman, D Ebers, G Parent-child concordance in multiple sclerosis. |
| title | Parent-child concordance in multiple sclerosis. |
| title_full | Parent-child concordance in multiple sclerosis. |
| title_fullStr | Parent-child concordance in multiple sclerosis. |
| title_full_unstemmed | Parent-child concordance in multiple sclerosis. |
| title_short | Parent-child concordance in multiple sclerosis. |
| title_sort | parent child concordance in multiple sclerosis |
| work_keys_str_mv | AT sadovnicka parentchildconcordanceinmultiplesclerosis AT bulmand parentchildconcordanceinmultiplesclerosis AT ebersg parentchildconcordanceinmultiplesclerosis |