Influence of pH on Ca²⁺ current and its control of electrical and Ca²⁺ signaling in ventricular myocytes.

Modulation of L-type Ca(2+) current (I(Ca,L)) by H(+) ions in cardiac myocytes is controversial, with widely discrepant responses reported. The pH sensitivity of I(Ca,L) was investigated (whole cell voltage clamp) while measuring intracellular Ca(2+) (Ca(2+)(i)) or pH(i) (epifluorescence microscopy)...

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Bibliographic Details
Main Authors: Saegusa, N, Moorhouse, E, Vaughan-Jones, R, Spitzer, K
Format: Journal article
Language:English
Published: 2011

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