Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity.

Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity.

HIF (hypoxia-inducible factor) is an alphabeta transcription factor that modulates the hypoxic response in many animals. The cellular abundance and activity of HIF-alpha are regulated by its post-translational hydroxylation. The hydroxylation of HIF is catalysed by PHD (prolyl hydroxylase domain) en...

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Bibliographic Details
Main Authors:	Lancaster, D, McNeill, L, McDonough, M, Aplin, RT, Hewitson, K, Pugh, C, Ratcliffe, P, Schofield, C
Format:	Journal article
Language:	English
Published:	2004

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