Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity.

Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity.

HIF (hypoxia-inducible factor) is an alphabeta transcription factor that modulates the hypoxic response in many animals. The cellular abundance and activity of HIF-alpha are regulated by its post-translational hydroxylation. The hydroxylation of HIF is catalysed by PHD (prolyl hydroxylase domain) en...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Lancaster, D, McNeill, L, McDonough, M, Aplin, RT, Hewitson, K, Pugh, C, Ratcliffe, P, Schofield, C
Formatua:	Journal article
Hizkuntza:	English
Argitaratua:	2004

Antzeko izenburuak

The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by beta-oxocarboxylic acids.
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Factor inhibiting hypoxia-inducible factor (FIH) and other asparaginyl hydroxylases.
nork: Lancaster, D, et al.
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Selective inhibition of factor inhibiting hypoxia-inducible factor.
nork: McDonough, M, et al.
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Inhibition of hypoxia inducible factor (HIF) hydroxylases
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Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH).
nork: Cockman, M, et al.
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Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family.
nork: Hewitson, K, et al.
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Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains.
nork: Yang, M, et al.
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Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor.
nork: Conejo-Garcia, A, et al.
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Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH).
nork: Hewitson, K, et al.
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Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha.
nork: Elkins, J, et al.
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Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803.
nork: McNeill, L, et al.
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Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates.
nork: Hewitson, K, et al.
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Inhibition of the oxygen-sensing asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor: a potential hypoxia response modulating strategy
nork: Wu, Y, et al.
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Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor.
nork: Coleman, M, et al.
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MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH).
nork: Webb, J, et al.
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Substrate selectivity analyses of factor inhibiting hypoxia-inducible factor.
nork: Yang, M, et al.
Argitaratua: (2013)

Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) in regulating hypoxia-inducible factor (HIF) transcriptional target genes [corrected].
nork: Stolze, I, et al.
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Investigating the role of factor inhibiting HIF (FIH) in tumourigenesis
nork: Ma, J
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Factor inhibiting HIF (FIH1) modulates cardiac function and metabolism
nork: Holliday, J, et al.
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Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor
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Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor.
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Proteomics-based identification of novel factor inhibiting hypoxia-inducible factor (FIH) substrates indicates widespread asparaginyl hydroxylation of ankyrin repeat domain-containing proteins.
nork: Cockman, M, et al.
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Modulating the hypoxia-inducible factor signaling pathway: applications from cardiovascular disease to cancer.
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Factor-inhibiting HIF-1 (FIH-1) is required for human vascular endothelial cell survival
nork: Kiriakidis, S, et al.
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The selectivity and inhibition of AlkB.
nork: Welford, R, et al.
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Quantitative mass spectrometry reveals dynamics of factor-inhibiting hypoxia-inducible factor-catalyzed hydroxylation
nork: Singleton, R, et al.
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Quantitative mass spectrometry reveals dynamics of factor-inhibiting hypoxia-inducible factor-catalyzed hydroxylation.
nork: Singleton, R, et al.
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Inhibition studies on hypoxia-inducible factor (HIF) hydroxylases
nork: Chan, M
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Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases.
nork: Chowdhury, R, et al.
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Inhibition of hypoxia-inducible factor activity with Carica papaya extracts
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Studies on the inhibition of human hypoxia inducible factor (HIF) hydroxylases
nork: Yeoh, KK
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New structural insights into the inhibition of serine proteases by cyclic peptides from bacteria.
nork: McDonough, M, et al.
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Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2).
nork: McDonough, M, et al.
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Inhibition of 2-oxoglutarate dependent oxygenases.
nork: Rose, N, et al.
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Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha.
nork: Pollard, P, et al.
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Hypoxia-inducible factor prolyl-hydroxylase: purification and assays of PHD2.
nork: Hewitson, K, et al.
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Factor inhibiting HIF (FIH-1) promotes renal cancer cell survival by protecting cells from HIF-1α-mediated apoptosis.
nork: Khan, M, et al.
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Structural, biochemical and inhibition studies on hypoxia-inducible factor (HIF) prolyl hydroxylases
nork: Lippl, K
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Hypoxia inducible factors inhibit respiratory syncytial virus infection by modulation of nucleolin expression
nork: Zhuang, X, et al.
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Tuning the transcriptional response to hypoxia by inhibiting HIF prolyl- and asparaginyl-hydroxylases
nork: Chan, M, et al.
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