Expression of prolyl-hydroxylases PHD-1, 2 and 3 and of the asparagine hydroxylase FIH in non-small cell lung cancer relates to an activated HIF pathway

Expression of prolyl-hydroxylases PHD-1, 2 and 3 and of the asparagine hydroxylase FIH in non-small cell lung cancer relates to an activated HIF pathway

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The oxygen sensitive prolyl-hydroxylase domain enzymes (PHDs) and the asparagines hydroxylase (FIH, factor inhibiting HIF) regulate the transcriptional activity of HIFs. We assessed the expression of these enzymes in a series of 73 non-small cell lung carcinomas (NSCLC). A direct association of PHDs...

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Bibliographic Details
Main Authors:	Giatromanolaki, A, Koukourakis, M, Pezzella, F, Turley, H, Sivridis, E, Bouros, D, Bougioukas, G, Harris, A, Gatter, K
Format:	Journal article
Language:	English
Published:	2008

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