Experimental validation of a tractable numerical model for focused ultrasound heating in flow-through tissue phantoms
<p style="text-align:justify;"> Heating from high intensity focused ultrasound (HIFU) can be used to control bleeding, both from individual blood vessels as well as from gross damage to the capillary bed. The presence of vascularity can limit one’s ability to elevate the temperature...
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| Format: | Journal article |
| Language: | English |
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Acoustical Society of America
2004
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| _version_ | 1826305890370715648 |
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| author | Huang, J Holt, RG Cleveland, RO Roy, RA |
| author_facet | Huang, J Holt, RG Cleveland, RO Roy, RA |
| author_sort | Huang, J |
| collection | OXFORD |
| description | <p style="text-align:justify;"> Heating from high intensity focused ultrasound (HIFU) can be used to control bleeding, both from individual blood vessels as well as from gross damage to the capillary bed. The presence of vascularity can limit one’s ability to elevate the temperature owing to convective heat transport. In an effort to better understand the heating process in tissues with vascular structure we have developed a numerical simulation that couples models for ultrasound propagation, acoustic streaming, ultrasound heating and blood cooling in a Newtonian viscous medium. The 3-D simulation allows for the study of complicated biological structures and insonation geometries. We have also undertaken a series of in vitro experiments employing non-uniform flow-through tissue phantoms and designed to provide verification of the model predictions. We show that blood flow of 2 cm/s (6.4 ml/min through a 2.6 mm ‘vessel’) can reduce peak temperature in a vessel wall by 25%. We also show that HIFU intensities of <math altimg="eq-00001.gif" overflow="scroll"><msup><mtext>6.5×10</mtext><mrow><mn>5</mn></mrow></msup><mi> </mi><msup><mi mathvariant="normal">W/m</mi><mrow><mn>2</mn></mrow></msup></math> can induce acoustic streaming with peak velocities up to 5 cm/s and this can reduce heating near a vessel wall by more than 10%. These results demonstrate that convective cooling is important in HIFU and can be accounted for within simulation models. </p> |
| first_indexed | 2024-03-07T06:39:41Z |
| format | Journal article |
| id | oxford-uuid:f8d5307b-86db-41d7-a8cb-0df0effb5a50 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:39:41Z |
| publishDate | 2004 |
| publisher | Acoustical Society of America |
| record_format | dspace |
| spelling | oxford-uuid:f8d5307b-86db-41d7-a8cb-0df0effb5a502022-03-27T12:53:33ZExperimental validation of a tractable numerical model for focused ultrasound heating in flow-through tissue phantomsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f8d5307b-86db-41d7-a8cb-0df0effb5a50EnglishSymplectic Elements at OxfordAcoustical Society of America2004Huang, JHolt, RGCleveland, RORoy, RA <p style="text-align:justify;"> Heating from high intensity focused ultrasound (HIFU) can be used to control bleeding, both from individual blood vessels as well as from gross damage to the capillary bed. The presence of vascularity can limit one’s ability to elevate the temperature owing to convective heat transport. In an effort to better understand the heating process in tissues with vascular structure we have developed a numerical simulation that couples models for ultrasound propagation, acoustic streaming, ultrasound heating and blood cooling in a Newtonian viscous medium. The 3-D simulation allows for the study of complicated biological structures and insonation geometries. We have also undertaken a series of in vitro experiments employing non-uniform flow-through tissue phantoms and designed to provide verification of the model predictions. We show that blood flow of 2 cm/s (6.4 ml/min through a 2.6 mm ‘vessel’) can reduce peak temperature in a vessel wall by 25%. We also show that HIFU intensities of <math altimg="eq-00001.gif" overflow="scroll"><msup><mtext>6.5×10</mtext><mrow><mn>5</mn></mrow></msup><mi> </mi><msup><mi mathvariant="normal">W/m</mi><mrow><mn>2</mn></mrow></msup></math> can induce acoustic streaming with peak velocities up to 5 cm/s and this can reduce heating near a vessel wall by more than 10%. These results demonstrate that convective cooling is important in HIFU and can be accounted for within simulation models. </p> |
| spellingShingle | Huang, J Holt, RG Cleveland, RO Roy, RA Experimental validation of a tractable numerical model for focused ultrasound heating in flow-through tissue phantoms |
| title | Experimental validation of a tractable numerical model for focused ultrasound heating in flow-through tissue phantoms |
| title_full | Experimental validation of a tractable numerical model for focused ultrasound heating in flow-through tissue phantoms |
| title_fullStr | Experimental validation of a tractable numerical model for focused ultrasound heating in flow-through tissue phantoms |
| title_full_unstemmed | Experimental validation of a tractable numerical model for focused ultrasound heating in flow-through tissue phantoms |
| title_short | Experimental validation of a tractable numerical model for focused ultrasound heating in flow-through tissue phantoms |
| title_sort | experimental validation of a tractable numerical model for focused ultrasound heating in flow through tissue phantoms |
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