Translational opportunities of single-cell biology in atherosclerosis
The advent of single-cell biology opens a new chapter for understanding human biological processes and for diagnosing, monitoring, and treating disease. This revolution now reaches the field of cardiovascular disease (CVD). New technologies to interrogate CVD samples at single-cell resolution are al...
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Oxford University Press
2022
|
| _version_ | 1797109546207936512 |
|---|---|
| author | de Winther, MPJ Bäck, M Evans, P Gomez, D Goncalves, I Jørgensen, HF Koenen, RR Lutgens, E Norata, GD Osto, E Dib, L Simons, M Stellos, K Ylä-Herttuala, S Winkels, H Bochaton-Piallat, M-L Monaco, C |
| author_facet | de Winther, MPJ Bäck, M Evans, P Gomez, D Goncalves, I Jørgensen, HF Koenen, RR Lutgens, E Norata, GD Osto, E Dib, L Simons, M Stellos, K Ylä-Herttuala, S Winkels, H Bochaton-Piallat, M-L Monaco, C |
| author_sort | de Winther, MPJ |
| collection | OXFORD |
| description | The advent of single-cell biology opens a new chapter for understanding human biological processes and for diagnosing, monitoring, and treating disease. This revolution now reaches the field of cardiovascular disease (CVD). New technologies to interrogate CVD samples at single-cell resolution are allowing the identification of novel cell communities that are important in shaping disease development and direct towards new therapeutic strategies. These approaches have begun to revolutionize atherosclerosis pathology and redraw our understanding of disease development. This review discusses the state-of-the-art of single-cell analysis of atherosclerotic plaques, with a particular focus on human lesions, and presents the current resolution of cellular subpopulations and their heterogeneity and plasticity in relation to clinically relevant features. Opportunities and pitfalls of current technologies as well as the clinical impact of single-cell technologies in CVD patient care are highlighted, advocating for multidisciplinary and international collaborative efforts to join the cellular dots of CVD. |
| first_indexed | 2024-03-07T07:43:15Z |
| format | Journal article |
| id | oxford-uuid:f8f02a81-1092-42eb-acd3-8dbac09939c5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:43:15Z |
| publishDate | 2022 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:f8f02a81-1092-42eb-acd3-8dbac09939c52023-05-02T16:55:42ZTranslational opportunities of single-cell biology in atherosclerosisJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f8f02a81-1092-42eb-acd3-8dbac09939c5EnglishSymplectic ElementsOxford University Press2022de Winther, MPJBäck, MEvans, PGomez, DGoncalves, IJørgensen, HFKoenen, RRLutgens, ENorata, GDOsto, EDib, LSimons, MStellos, KYlä-Herttuala, SWinkels, HBochaton-Piallat, M-LMonaco, CThe advent of single-cell biology opens a new chapter for understanding human biological processes and for diagnosing, monitoring, and treating disease. This revolution now reaches the field of cardiovascular disease (CVD). New technologies to interrogate CVD samples at single-cell resolution are allowing the identification of novel cell communities that are important in shaping disease development and direct towards new therapeutic strategies. These approaches have begun to revolutionize atherosclerosis pathology and redraw our understanding of disease development. This review discusses the state-of-the-art of single-cell analysis of atherosclerotic plaques, with a particular focus on human lesions, and presents the current resolution of cellular subpopulations and their heterogeneity and plasticity in relation to clinically relevant features. Opportunities and pitfalls of current technologies as well as the clinical impact of single-cell technologies in CVD patient care are highlighted, advocating for multidisciplinary and international collaborative efforts to join the cellular dots of CVD. |
| spellingShingle | de Winther, MPJ Bäck, M Evans, P Gomez, D Goncalves, I Jørgensen, HF Koenen, RR Lutgens, E Norata, GD Osto, E Dib, L Simons, M Stellos, K Ylä-Herttuala, S Winkels, H Bochaton-Piallat, M-L Monaco, C Translational opportunities of single-cell biology in atherosclerosis |
| title | Translational opportunities of single-cell biology in atherosclerosis |
| title_full | Translational opportunities of single-cell biology in atherosclerosis |
| title_fullStr | Translational opportunities of single-cell biology in atherosclerosis |
| title_full_unstemmed | Translational opportunities of single-cell biology in atherosclerosis |
| title_short | Translational opportunities of single-cell biology in atherosclerosis |
| title_sort | translational opportunities of single cell biology in atherosclerosis |
| work_keys_str_mv | AT dewinthermpj translationalopportunitiesofsinglecellbiologyinatherosclerosis AT backm translationalopportunitiesofsinglecellbiologyinatherosclerosis AT evansp translationalopportunitiesofsinglecellbiologyinatherosclerosis AT gomezd translationalopportunitiesofsinglecellbiologyinatherosclerosis AT goncalvesi translationalopportunitiesofsinglecellbiologyinatherosclerosis AT jørgensenhf translationalopportunitiesofsinglecellbiologyinatherosclerosis AT koenenrr translationalopportunitiesofsinglecellbiologyinatherosclerosis AT lutgense translationalopportunitiesofsinglecellbiologyinatherosclerosis AT noratagd translationalopportunitiesofsinglecellbiologyinatherosclerosis AT ostoe translationalopportunitiesofsinglecellbiologyinatherosclerosis AT dibl translationalopportunitiesofsinglecellbiologyinatherosclerosis AT simonsm translationalopportunitiesofsinglecellbiologyinatherosclerosis AT stellosk translationalopportunitiesofsinglecellbiologyinatherosclerosis AT ylaherttualas translationalopportunitiesofsinglecellbiologyinatherosclerosis AT winkelsh translationalopportunitiesofsinglecellbiologyinatherosclerosis AT bochatonpiallatml translationalopportunitiesofsinglecellbiologyinatherosclerosis AT monacoc translationalopportunitiesofsinglecellbiologyinatherosclerosis |