A miniaturized screen for inhibitors of Jumonji histone demethylases.

A miniaturized screen for inhibitors of Jumonji histone demethylases.

Show other versions (1)

2-Oxoglutarate- and Fe(ii)-dependent oxygenases are a major class of N(epsilon)-methyl lysine demethylases that are involved in epigenetic regulation. Assays suitable for implementation in a high-throughput manner have been lacking for these enzymes. Here, we describe the design and implementation o...

Fuld beskrivelse

Bibliografiske detaljer
Main Authors: Sakurai, M, Rose, N, Schultz, L, Quinn, A, Jadhav, A, Ng, S, Oppermann, U, Schofield, C, Simeonov, A
Format: Journal article
Sprog:English
Udgivet: 2010
Fag:
Kinetics
methods
Spectrometry, Fluorescence
Enzyme Inhibitors
pharmacology
Aldehyde Oxidoreductases
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
antagonists and inhibitors
Jumonji Domain-Containing Histone Demethylases
metabolism
Drug Discovery
Humans
Miniaturization

Lignende værker