Risk of fractures in patients with multiple sclerosis: record-linkage study.
BACKGROUND: Patients with multiple sclerosis (MS) have been reported to be at higher risk of fracture than other people. We sought to test this hypothesis in a large database of hospital admissions in England. METHODS: We analysed a database of linked statistical records of hospital admissions and...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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BioMed Central
2012
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| _version_ | 1797104910222753792 |
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| author | Ramagopalan, S Seminog, O Goldacre, R Goldacre, M |
| author_facet | Ramagopalan, S Seminog, O Goldacre, R Goldacre, M |
| author_sort | Ramagopalan, S |
| collection | OXFORD |
| description | BACKGROUND: Patients with multiple sclerosis (MS) have been reported to be at higher risk of fracture than other people. We sought to test this hypothesis in a large database of hospital admissions in England. METHODS: We analysed a database of linked statistical records of hospital admissions and death certificates for the whole of England (1999-2010). Rate ratios for fractures were determined, comparing fracture rates in a cohort of all people in England admitted with MS and rates in a comparison cohort. RESULTS: Significantly elevated risk for all fractures was found in patients with MS (rate ratio (RR) = 1.99, 95% confidence interval (CI) = 1.93-2.05)). Risks were particularly high for femoral fractures (femoral neck fracture RR = 2.79 (2.65-2.93); femoral shaft fracture RR 6.69 (6.12-7.29)), and fractures of the tibia or ankle RR = 2.81 (2.66-2.96). CONCLUSIONS: Patients with MS have an increased risk of fractures. Caregivers should aim to optimize bone health in MS patients. |
| first_indexed | 2024-03-07T06:40:08Z |
| format | Journal article |
| id | oxford-uuid:f8fcb452-f925-4cec-91ea-0a47447d48b3 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:40:08Z |
| publishDate | 2012 |
| publisher | BioMed Central |
| record_format | dspace |
| spelling | oxford-uuid:f8fcb452-f925-4cec-91ea-0a47447d48b32022-03-27T12:54:38ZRisk of fractures in patients with multiple sclerosis: record-linkage study.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f8fcb452-f925-4cec-91ea-0a47447d48b3OrthopaedicsMultiple SclerosisEnglishSymplectic Elements at OxfordBioMed Central2012Ramagopalan, SSeminog, OGoldacre, RGoldacre, M BACKGROUND: Patients with multiple sclerosis (MS) have been reported to be at higher risk of fracture than other people. We sought to test this hypothesis in a large database of hospital admissions in England. METHODS: We analysed a database of linked statistical records of hospital admissions and death certificates for the whole of England (1999-2010). Rate ratios for fractures were determined, comparing fracture rates in a cohort of all people in England admitted with MS and rates in a comparison cohort. RESULTS: Significantly elevated risk for all fractures was found in patients with MS (rate ratio (RR) = 1.99, 95% confidence interval (CI) = 1.93-2.05)). Risks were particularly high for femoral fractures (femoral neck fracture RR = 2.79 (2.65-2.93); femoral shaft fracture RR 6.69 (6.12-7.29)), and fractures of the tibia or ankle RR = 2.81 (2.66-2.96). CONCLUSIONS: Patients with MS have an increased risk of fractures. Caregivers should aim to optimize bone health in MS patients. |
| spellingShingle | Orthopaedics Multiple Sclerosis Ramagopalan, S Seminog, O Goldacre, R Goldacre, M Risk of fractures in patients with multiple sclerosis: record-linkage study. |
| title | Risk of fractures in patients with multiple sclerosis: record-linkage study. |
| title_full | Risk of fractures in patients with multiple sclerosis: record-linkage study. |
| title_fullStr | Risk of fractures in patients with multiple sclerosis: record-linkage study. |
| title_full_unstemmed | Risk of fractures in patients with multiple sclerosis: record-linkage study. |
| title_short | Risk of fractures in patients with multiple sclerosis: record-linkage study. |
| title_sort | risk of fractures in patients with multiple sclerosis record linkage study |
| topic | Orthopaedics Multiple Sclerosis |
| work_keys_str_mv | AT ramagopalans riskoffracturesinpatientswithmultiplesclerosisrecordlinkagestudy AT seminogo riskoffracturesinpatientswithmultiplesclerosisrecordlinkagestudy AT goldacrer riskoffracturesinpatientswithmultiplesclerosisrecordlinkagestudy AT goldacrem riskoffracturesinpatientswithmultiplesclerosisrecordlinkagestudy |