Mutagenesis of human DNA polymerase lambda: essential roles of Tyr505 and Phe506 for both DNA polymerase and terminal transferase activities.

Mutagenesis of human DNA polymerase lambda: essential roles of Tyr505 and Phe506 for both DNA polymerase and terminal transferase activities.

DNA polymerase (pol) lambda is homologous to pol beta and has intrinsic polymerase and terminal transferase activities. However, nothing is known about the amino acid residues involved in these activities. In order to precisely define the nucleotide-binding site of human pol lambda, we have mutageni...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Shevelev, I, Blanca, G, Villani, G, Ramadan, K, Spadari, S, Hübscher, U, Maga, G
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	2003

Παρόμοια τεκμήρια

De novo DNA synthesis by human DNA polymerase lambda, DNA polymerase mu and terminal deoxyribonucleotidyl transferase.
ανά: Ramadan, K, κ.ά.
Έκδοση: (2004)

DNA elongation by the human DNA polymerase lambda polymerase and terminal transferase activities are differentially coordinated by proliferating cell nuclear antigen and replication protein A.
ανά: Maga, G, κ.ά.
Έκδοση: (2005)

Human DNA polymerase lambda diverged in evolution from DNA polymerase beta toward specific Mn(++) dependence: a kinetic and thermodynamic study.
ανά: Blanca, G, κ.ά.
Έκδοση: (2003)

Human DNA polymerase lambda possesses terminal deoxyribonucleotidyl transferase activity and can elongate RNA primers: implications for novel functions.
ανά: Ramadan, K, κ.ά.
Έκδοση: (2003)

DNA polymerase lambda from calf thymus preferentially replicates damaged DNA.
ανά: Ramadan, K, κ.ά.
Έκδοση: (2002)

Human DNA polymerases lambda and beta show different efficiencies of translesion DNA synthesis past abasic sites and alternative mechanisms for frameshift generation.
ανά: Blanca, G, κ.ά.
Έκδοση: (2004)

Human DNA polymerase lambda functionally and physically interacts with proliferating cell nuclear antigen in normal and translesion DNA synthesis.
ανά: Maga, G, κ.ά.
Έκδοση: (2002)

The human DNA polymerase lambda interacts with PCNA through a domain important for DNA primer binding and the interaction is inhibited by p21/WAF1/CIP1.
ανά: Maga, G, κ.ά.
Έκδοση: (2004)

DNA polymerase theta purified from human cells is a high-fidelity enzyme.
ανά: Maga, G, κ.ά.
Έκδοση: (2002)

DNA polymerases and diseases
ανά: Ramadan, K, κ.ά.
Έκδοση: (2007)

Inhibition of mammalian DNA polymerases by resveratrol: mechanism and structural determinants.
ανά: Locatelli, G, κ.ά.
Έκδοση: (2005)

The DNA-polymerase-X family: controllers of DNA quality?
ανά: Ramadan, K, κ.ά.
Έκδοση: (2004)

The TREX2 3'-->5' exonuclease physically interacts with DNA polymerase delta and increases its accuracy.
ανά: Shevelev, I, κ.ά.
Έκδοση: (2002)

The TREX2 3′→ 5′ Exonuclease Physically Interacts with DNA Polymerase δ and Increases Its Accuracy
ανά: Igor V. Shevelev, κ.ά.
Έκδοση: (2002-01-01)

Mutant T4 DNA polymerase for easy cloning and mutagenesis.
ανά: Ruhu Qi, κ.ά.
Έκδοση: (2019-01-01)

Site-directed mutagenesis using Pfu DNA polymerase and T4 DNA ligase
ανά: Yair Adereth, κ.ά.
Έκδοση: (2005-06-01)

Addendum: Site-directed mutagenesis using Pfu DNA polymerase and T4 DNA ligase
Έκδοση: (2005-09-01)

T4 DNA polymerase improves the efficiency of multiple site-directed mutagenesis
ανά: Wei Guo, κ.ά.
Έκδοση: (2016-07-01)

[PROVISIONAL] Role of error-prone DNA polymerases in spontaneous mutagenesis in Caulobacter crescentus
ανά: Alexy O. Valencia, κ.ά.

Modification of 3’ Terminal Ends of DNA and RNA Using DNA Polymerase θ Terminal Transferase Activity
ανά: Trung Hoang, κ.ά.
Έκδοση: (2017-06-01)

Silencing of human DNA polymerase λ causes replication stress and is synthetically lethal with an impaired S phase checkpoint.
ανά: Zucca, E, κ.ά.
Έκδοση: (2013)

DNA polymerase ε and δ variants drive mutagenesis in polypurine tracts in human tumors
ανά: Daria Ostroverkhova, κ.ά.
Έκδοση: (2024-01-01)

Arabidopsis DNA polymerase lambda mutant is mildly sensitive to DNA double strand breaks but defective in integration ofa transgene.
ανά: Tomoyuki eFurukawa, κ.ά.
Έκδοση: (2015-05-01)

DNA Polymerase e - More Than a Polymerase
ανά: Helmut Pospiech, κ.ά.
Έκδοση: (2003-01-01)

Bacterial DNA, DNA polymerase, and DNA helicases /
ανά: Knudsen, Walter D., κ.ά.
Έκδοση: (c201)

Regulation of oxidative DNA damage repair by DNA polymerase λ and MutYH by cross-talk of phosphorylation and ubiquitination.
ανά: Markkanen, E, κ.ά.
Έκδοση: (2012)

DNA polymerase κ suppresses inflammation and inflammation-induced mutagenesis and carcinogenic potential in the colon of mice
ανά: Atsushi Hakura, κ.ά.
Έκδοση: (2023-04-01)

A new family of polymerases related to superfamily A DNA polymerases and T7-like DNA-dependent RNA polymerases
ανά: Aravind L, κ.ά.
Έκδοση: (2008-10-01)

Isothermal Amplification and Multimerization of DNA by Bst DNA Polymerase
ανά: G.J. Hafner, κ.ά.
Έκδοση: (2001-04-01)

Impact of ribonucleotide incorporation by DNA polymerases β and λ on oxidative base excision repair
ανά: Emmanuele Crespan, κ.ά.
Έκδοση: (2016-02-01)

Collision with duplex DNA renders Escherichia coli DNA polymerase III holoenzyme susceptible to DNA polymerase IV-mediated polymerase switching on the sliding clamp
ανά: Thanh Thi Le, κ.ά.
Έκδοση: (2017-10-01)

DNA Polymerases as Engines for Biotechnology
ανά: Scott C. Hamilton, κ.ά.
Έκδοση: (2001-08-01)

The DNA polymerases of Drosophila melanogaster
ανά: Steven J. Marygold, κ.ά.
Έκδοση: (2020-10-01)

The Role OF DNA Polymerases in Carcinogenesis
ανά: Zahra Aghelan, κ.ά.
Έκδοση: (2016-07-01)

MMS exposure promotes increased MtDNA mutagenesis in the presence of replication-defective disease-associated DNA polymerase γ variants.
ανά: Jeffrey D Stumpf, κ.ά.
Έκδοση: (2014-10-01)

Dual activities of an X-family DNA polymerase regulate CRISPR-induced insertional mutagenesis across species
ανά: Trevor Weiss, κ.ά.
Έκδοση: (2024-07-01)

Use of T4 DNA Polymerase to Create Cohesive Termini in PCR Products for Subcloning and Site-Directed Mutagenesis
ανά: Austin J. Cooney
Έκδοση: (1998-01-01)

Primer-Directed Mutagenesis of an Intact Plasmid by Using Pwo DNA Polymerase in Long Distance Inverse PCR
ανά: Rachmat Hidajat, κ.ά.
Έκδοση: (1997-01-01)

DNA polymerases beta and lambda mediate overlapping and independent roles in base excision repair in mouse embryonic fibroblasts
ανά: Braithwaite, Elena K., κ.ά.
Έκδοση: (2011)

DNA polymerases beta and lambda mediate overlapping and independent roles in base excision repair in mouse embryonic fibroblasts.
ανά: Elena K Braithwaite, κ.ά.
Έκδοση: (2010-08-01)