Is Dupuytren’s disease really a “disease of the Vikings”?
It has been suggested that Dupuytren’s disease has an origin in Norse countries. We harnessed data from a genome-wide association study of Dupuytren’s disease and the People of the British Isles study to determine evidence for a Norse origin of Dupuytren’s disease. We computed Wright’s Fixation Inde...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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SAGE Publications
2019
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| _version_ | 1797109788548530176 |
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| author | Ng, M Lawson, DJ Winney, B Furniss, D |
| author_facet | Ng, M Lawson, DJ Winney, B Furniss, D |
| author_sort | Ng, M |
| collection | OXFORD |
| description | It has been suggested that Dupuytren’s disease has an origin in Norse countries. We harnessed data from a genome-wide association study of Dupuytren’s disease and the People of the British Isles study to determine evidence for a Norse origin of Dupuytren’s disease. We computed Wright’s Fixation Index between Orkney (Norse ancestry), Wales (ancient British) and South East England (Anglo-Saxons); compared mean Wright’s Fixation Index in cases versus controls; used permutation to determine any excess of Norse inheritance in disease associated variants; constructed a genetic risk score for Dupuytren’s disease and applied this to the People of the British Isles dataset to look for systematic differences between counties with known high and low levels of Norse ancestry. Finally, chromosome painting was used to see whether Dupuytren’s disease-associated single nucleotide polymorphisms are geographically structured. In all analyses, no evidence was found for an excess of Norse ancestry in Dupuytren’s disease. We conclude that there is no genetic evidence for a ‘Viking origin of Dupuytren’s disease’. |
| first_indexed | 2024-03-07T07:46:15Z |
| format | Journal article |
| id | oxford-uuid:f925b1cd-9690-424b-bc15-c6250bbedf3b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:46:15Z |
| publishDate | 2019 |
| publisher | SAGE Publications |
| record_format | dspace |
| spelling | oxford-uuid:f925b1cd-9690-424b-bc15-c6250bbedf3b2023-06-08T09:05:54ZIs Dupuytren’s disease really a “disease of the Vikings”?Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f925b1cd-9690-424b-bc15-c6250bbedf3bEnglishSymplectic Elements at OxfordSAGE Publications2019Ng, MLawson, DJWinney, BFurniss, DIt has been suggested that Dupuytren’s disease has an origin in Norse countries. We harnessed data from a genome-wide association study of Dupuytren’s disease and the People of the British Isles study to determine evidence for a Norse origin of Dupuytren’s disease. We computed Wright’s Fixation Index between Orkney (Norse ancestry), Wales (ancient British) and South East England (Anglo-Saxons); compared mean Wright’s Fixation Index in cases versus controls; used permutation to determine any excess of Norse inheritance in disease associated variants; constructed a genetic risk score for Dupuytren’s disease and applied this to the People of the British Isles dataset to look for systematic differences between counties with known high and low levels of Norse ancestry. Finally, chromosome painting was used to see whether Dupuytren’s disease-associated single nucleotide polymorphisms are geographically structured. In all analyses, no evidence was found for an excess of Norse ancestry in Dupuytren’s disease. We conclude that there is no genetic evidence for a ‘Viking origin of Dupuytren’s disease’. |
| spellingShingle | Ng, M Lawson, DJ Winney, B Furniss, D Is Dupuytren’s disease really a “disease of the Vikings”? |
| title | Is Dupuytren’s disease really a “disease of the Vikings”? |
| title_full | Is Dupuytren’s disease really a “disease of the Vikings”? |
| title_fullStr | Is Dupuytren’s disease really a “disease of the Vikings”? |
| title_full_unstemmed | Is Dupuytren’s disease really a “disease of the Vikings”? |
| title_short | Is Dupuytren’s disease really a “disease of the Vikings”? |
| title_sort | is dupuytren s disease really a disease of the vikings |
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