Incidence rates of autoimmune diseases in European healthcare databases: a contribution of the ADVANCE project
Introduction The public–private ADVANCE collaboration developed and tested a system to generate evidence on vaccine benefits and risks using European electronic healthcare databases. In the safety of vaccines, background incidence rates are key to allow proper monitoring and assessment. The goals of...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Springer
2021
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| _version_ | 1797104946949128192 |
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| author | Willame, C Dodd, C van der Aa, L Picelli, G Emborg, H-D Kahlert, J Gini, R Huerta, C Martín-Merino, E McGee, C de Lusignan, S Roberto, G Villa, M Weibel, D Titievsky, L Sturkenboom, MCJM |
| author_facet | Willame, C Dodd, C van der Aa, L Picelli, G Emborg, H-D Kahlert, J Gini, R Huerta, C Martín-Merino, E McGee, C de Lusignan, S Roberto, G Villa, M Weibel, D Titievsky, L Sturkenboom, MCJM |
| author_sort | Willame, C |
| collection | OXFORD |
| description | Introduction
The public–private ADVANCE collaboration developed and tested a system to generate evidence on vaccine benefits and risks using European electronic healthcare databases. In the safety of vaccines, background incidence rates are key to allow proper monitoring and assessment. The goals of this study were to compute age-, sex-, and calendar-year stratified incidence rates of nine autoimmune diseases in seven European healthcare databases from four countries and to assess validity by comparing with published data.
Methods
Event rates were calculated for the following outcomes: acute disseminated encephalomyelitis, Bell’s palsy, Guillain–Barré syndrome, immune thrombocytopenia purpura, Kawasaki disease, optic neuritis, narcolepsy, systemic lupus erythematosus, and transverse myelitis. Cases were identified by diagnosis codes. Participating organizations/databases originated from Denmark, Italy, Spain, and the UK. The source population comprised all persons registered, with at least 1 year of data prior to the study start, or follow-up from birth. Stratified incidence rates were computed per database over the period 2003 to 2014.
Results
Between 2003 and 2014, 148,947 incident cases of nine autoimmune diseases were identified. Crude incidence rates were highest for Bell’s palsy [23.8/100,000 person-years (PYs), 95% confidence interval (CI) 23.6–24.1] and lowest for Kawasaki disease (0.7/100,000 PYs, 95% CI 0.6–0.7). Specific patterns were observed by sex, age, calendar time, and data sources. Rates were comparable with published estimates.
Conclusion
A range of autoimmune events could be identified in the ADVANCE system. Estimation of rates indicated consistency across selected European healthcare databases, as well as consistency with US published data.
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| first_indexed | 2024-03-07T06:40:35Z |
| format | Journal article |
| id | oxford-uuid:f9262361-a412-4750-b942-b8b60c4a86e8 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:40:35Z |
| publishDate | 2021 |
| publisher | Springer |
| record_format | dspace |
| spelling | oxford-uuid:f9262361-a412-4750-b942-b8b60c4a86e82022-03-27T12:55:47ZIncidence rates of autoimmune diseases in European healthcare databases: a contribution of the ADVANCE projectJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f9262361-a412-4750-b942-b8b60c4a86e8EnglishSymplectic ElementsSpringer2021Willame, CDodd, Cvan der Aa, LPicelli, GEmborg, H-DKahlert, JGini, RHuerta, CMartín-Merino, EMcGee, Cde Lusignan, SRoberto, GVilla, MWeibel, DTitievsky, LSturkenboom, MCJMIntroduction The public–private ADVANCE collaboration developed and tested a system to generate evidence on vaccine benefits and risks using European electronic healthcare databases. In the safety of vaccines, background incidence rates are key to allow proper monitoring and assessment. The goals of this study were to compute age-, sex-, and calendar-year stratified incidence rates of nine autoimmune diseases in seven European healthcare databases from four countries and to assess validity by comparing with published data. Methods Event rates were calculated for the following outcomes: acute disseminated encephalomyelitis, Bell’s palsy, Guillain–Barré syndrome, immune thrombocytopenia purpura, Kawasaki disease, optic neuritis, narcolepsy, systemic lupus erythematosus, and transverse myelitis. Cases were identified by diagnosis codes. Participating organizations/databases originated from Denmark, Italy, Spain, and the UK. The source population comprised all persons registered, with at least 1 year of data prior to the study start, or follow-up from birth. Stratified incidence rates were computed per database over the period 2003 to 2014. Results Between 2003 and 2014, 148,947 incident cases of nine autoimmune diseases were identified. Crude incidence rates were highest for Bell’s palsy [23.8/100,000 person-years (PYs), 95% confidence interval (CI) 23.6–24.1] and lowest for Kawasaki disease (0.7/100,000 PYs, 95% CI 0.6–0.7). Specific patterns were observed by sex, age, calendar time, and data sources. Rates were comparable with published estimates. Conclusion A range of autoimmune events could be identified in the ADVANCE system. Estimation of rates indicated consistency across selected European healthcare databases, as well as consistency with US published data. |
| spellingShingle | Willame, C Dodd, C van der Aa, L Picelli, G Emborg, H-D Kahlert, J Gini, R Huerta, C Martín-Merino, E McGee, C de Lusignan, S Roberto, G Villa, M Weibel, D Titievsky, L Sturkenboom, MCJM Incidence rates of autoimmune diseases in European healthcare databases: a contribution of the ADVANCE project |
| title | Incidence rates of autoimmune diseases in European healthcare databases: a contribution of the ADVANCE project |
| title_full | Incidence rates of autoimmune diseases in European healthcare databases: a contribution of the ADVANCE project |
| title_fullStr | Incidence rates of autoimmune diseases in European healthcare databases: a contribution of the ADVANCE project |
| title_full_unstemmed | Incidence rates of autoimmune diseases in European healthcare databases: a contribution of the ADVANCE project |
| title_short | Incidence rates of autoimmune diseases in European healthcare databases: a contribution of the ADVANCE project |
| title_sort | incidence rates of autoimmune diseases in european healthcare databases a contribution of the advance project |
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