A large-scale association analysis of common variation of the HNF1alpha gene with type 2 diabetes in the U.K. Caucasian population.

A large-scale association analysis of common variation of the HNF1alpha gene with type 2 diabetes in the U.K. Caucasian population.

HNF1alpha (TCF1) is a key transcription factor that is essential for pancreatic beta-cell development and function. Rare mutations of HNF1alpha cause maturity-onset diabetes of the young. A common variant, G319S, private to the Oji-Cree population, predisposes to type 2 diabetes, but the role of com...

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Detalhes bibliográficos
Principais autores:	Weedon, M, Owen, K, Shields, B, Hitman, G, Walker, M, McCarthy, M, Hattersley, A, Frayling, T
Formato:	Journal article
Idioma:	English
Publicado em:	2005

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