Activation of RAF/MEK/ERK and PI3K/AKT/mTOR pathways in pituitary adenomas and their effects on downstream effectors.

Activation of RAF/MEK/ERK and PI3K/AKT/mTOR pathways in pituitary adenomas and their effects on downstream effectors.

Raf/MEK/ERK and phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) cascades are key signalling pathways interacting with each other to regulate cell growth and tumourigenesis. We have previously shown B-Raf and Akt overexpression and/or overactivation in pituitary adenomas...

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Hlavní autoři: Dworakowska, D, Wlodek, E, Leontiou, C, Igreja, S, Cakir, M, Teng, M, Prodromou, N, Góth, M, Grozinsky-Glasberg, S, Gueorguiev, M, Kola, B, Korbonits, M, Grossman, AB
Médium: Journal article
Jazyk:English
Vydáno: 2009

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