Covalently attached intercalators restore duplex stability and splice-switching activity to triazole-modified oligonucleotides

Covalently attached intercalators restore duplex stability and splice-switching activity to triazole-modified oligonucleotides

Oligonucleotides are rapidly emerging as powerful therapeutics for hard to treat diseases. Short single-stranded oligonucleotides can base pair with target RNA and alter gene expression, providing an attractive therapeutic approach at the genetic level. Whilst conceptually appealing, oligonucleotide...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों:	Dysko, A, Baker, YR, McClorey, G, Wood, MJA, Fenner, S, Williams, G, El-Sagheer, A, Brown, T
स्वरूप:	Journal article
भाषा:	English
प्रकाशित:	Royal Society of Chemistry 2022

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