Covalently attached intercalators restore duplex stability and splice-switching activity to triazole-modified oligonucleotides

Covalently attached intercalators restore duplex stability and splice-switching activity to triazole-modified oligonucleotides

Oligonucleotides are rapidly emerging as powerful therapeutics for hard to treat diseases. Short single-stranded oligonucleotides can base pair with target RNA and alter gene expression, providing an attractive therapeutic approach at the genetic level. Whilst conceptually appealing, oligonucleotide...

Полное описание

Библиографические подробности
Главные авторы:	Dysko, A, Baker, YR, McClorey, G, Wood, MJA, Fenner, S, Williams, G, El-Sagheer, A, Brown, T
Формат:	Journal article
Язык:	English
Опубликовано:	Royal Society of Chemistry 2022

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