Covalently attached intercalators restore duplex stability and splice-switching activity to triazole-modified oligonucleotides
Oligonucleotides are rapidly emerging as powerful therapeutics for hard to treat diseases. Short single-stranded oligonucleotides can base pair with target RNA and alter gene expression, providing an attractive therapeutic approach at the genetic level. Whilst conceptually appealing, oligonucleotide...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Jezik: | English |
| Izdano: |
Royal Society of Chemistry
2022
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