Insights into the structural nature of the transition state in the Kir channel gating pathway.

Insights into the structural nature of the transition state in the Kir channel gating pathway.

In a previous study we identified an extensive gating network within the inwardly rectifying Kir1.1 (ROMK) channel by combining systematic scanning mutagenesis and functional analysis with structural models of the channel in the closed, pre-open and open states. This extensive network appeared to st...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Fowler, P, Bollepalli, M, Rapedius, M, Nematian-Ardestani, E, Shang, L, Sansom, MS, Tucker, S, Baukrowitz, T
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	2014

Παρόμοια τεκμήρια

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Conformational rearrangements during PIP2 gating in Kir channels
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State-dependent network connectivity determines gating in a K+ channel.
ανά: Bollepalli, M, κ.ά.
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ανά: Schewe, M, κ.ά.
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ανά: Rapedius, M, κ.ά.
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Structural and functional analysis of the putative pH sensor in the Kir1.1 (ROMK) potassium channel.
ανά: Rapedius, M, κ.ά.
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Structural and Mechanistic Insights into Gating of K2P Channels
ανά: Rapedius, M, κ.ά.
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Random mutagenesis screening indicates the absence of a separate H(+)-sensor in the pH-sensitive Kir channels.
ανά: Paynter, J, κ.ά.
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Random mutagenesis screening indicates the absence of a separate H(+)-sensor in the pH-sensitive Kir channels.
ανά: Paynter, J, κ.ά.
Έκδοση: (2010)

Random mutagenesis screening indicates the absence of a separate H+-sensor in the pH-sensitive Kir channels
ανά: Paynter, J, κ.ά.
Έκδοση: (2010)

The pore structure and gating mechanism of K2P channels.
ανά: Piechotta, P, κ.ά.
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The pore structure and gating mechanism of K2P channels
ανά: Piechotta, P, κ.ά.
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ανά: Schewe, M, κ.ά.
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The pore structure and gating mechanism of K2P channels (vol 30, pg 3607, 2011)
ανά: Piechotta, P, κ.ά.
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Non-equivalent role of TM2 gating hinges in heteromeric Kir4.1/Kir5.1 potassium channels.
ανά: Shang, L, κ.ά.
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ανά: Paynter, J, κ.ά.
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ανά: Zubcevic, L, κ.ά.
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ανά: Bavro, V, κ.ά.
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Structure of a KirBac potassium channel with an open bundle crossing indicates a mechanism of channel gating.
ανά: Bavro, V, κ.ά.
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Functional complementation and genetic deletion studies of KirBac channels: Activatory mutations highlight gating-sensitive domains
ανά: Paynter, J, κ.ά.
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K2P and Kir K+ Channels in Physiological Bilayers
ανά: Schmidt, MR, κ.ά.
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Molecular dynamics simulations of inwardly rectifying (Kir) potassium channels: a comparative study.
ανά: Haider, S, κ.ά.
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Hydrophobic gating in ion channels.
ανά: Aryal, P, κ.ά.
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Voltage-dependent gating in a "voltage sensor-less" ion channel.
ανά: Harley T Kurata, κ.ά.
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Simulating PIP2-Induced Gating Transitions in Kir6.2 Channels
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ανά: Grottesi, A, κ.ά.
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The effects of stretch activation on ionic selectivity of the TREK-2 K2P K(+) channel
ανά: Nematian-Ardestani, E, κ.ά.
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ανά: Casamassima, M, κ.ά.
Έκδοση: (2003)

Kir5.1 underlies long-lived subconductance levels in heteromeric Kir4.1/Kir5.1 channels from Xenopus tropicalis.
ανά: Shang, L, κ.ά.
Έκδοση: (2009)

Selectivity filter instability dominates the low intrinsic activity of the TWIK-1 K2P K+ channel
ανά: Nematian-Ardestani, E, κ.ά.
Έκδοση: (2019)

Conformational dynamics of M2 helices in KirBac channels: helix flexibility in relation to gating via molecular dynamics simulations.
ανά: Grottesi, A, κ.ά.
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State-independent intracellular access of quaternary ammonium blockers to the pore of TREK-1.
ανά: Rapedius, M, κ.ά.
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