Insights into the structural nature of the transition state in the Kir channel gating pathway.

Insights into the structural nature of the transition state in the Kir channel gating pathway.

In a previous study we identified an extensive gating network within the inwardly rectifying Kir1.1 (ROMK) channel by combining systematic scanning mutagenesis and functional analysis with structural models of the channel in the closed, pre-open and open states. This extensive network appeared to st...

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Bibliografische gegevens
Hoofdauteurs:	Fowler, P, Bollepalli, M, Rapedius, M, Nematian-Ardestani, E, Shang, L, Sansom, MS, Tucker, S, Baukrowitz, T
Formaat:	Journal article
Taal:	English
Gepubliceerd in:	2014

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State-dependent network connectivity determines gating in a K+ channel.
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A novel mechanism of voltage sensing and gating in K2P potassium channels
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A Novel Mechanism of Voltage Sensing and Gating in K2P Potassium Channels
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A novel mechanism of voltage sensing and gating in K2P potassium channels
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Structural and functional analysis of the putative pH sensor in the Kir1.1 (ROMK) potassium channel.
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Structural and Mechanistic Insights into Gating of K2P Channels
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Random mutagenesis screening indicates the absence of a separate H(+)-sensor in the pH-sensitive Kir channels.
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Random mutagenesis screening indicates the absence of a separate H(+)-sensor in the pH-sensitive Kir channels.
door: Paynter, J, et al.
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Random mutagenesis screening indicates the absence of a separate H+-sensor in the pH-sensitive Kir channels
door: Paynter, J, et al.
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The pore structure and gating mechanism of K2P channels.
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The pore structure and gating mechanism of K2P channels
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K2P and Kir K+ Channels in Physiological Bilayers
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Molecular dynamics simulations of inwardly rectifying (Kir) potassium channels: a comparative study.
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Voltage-dependent gating in a "voltage sensor-less" ion channel.
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Simulating PIP2-Induced Gating Transitions in Kir6.2 Channels
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The effects of stretch activation on ionic selectivity of the TREK-2 K2P K(+) channel
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Identification of a heteromeric interaction that influences the rectification, gating, and pH sensitivity of Kir4.1/Kir5.1 potassium channels.
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Kir5.1 underlies long-lived subconductance levels in heteromeric Kir4.1/Kir5.1 channels from Xenopus tropicalis.
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door: Grottesi, A, et al.
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State-independent intracellular access of quaternary ammonium blockers to the pore of TREK-1.
door: Rapedius, M, et al.
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