Patched 1 expression correlates with biochemical relapse in high-risk prostate cancer patients
There is an unmet clinical need for adequate biomarkers to aid risk stratification and management of prostate cancer (PCa) patients. Even within the high-risk PCa category not all patients will invariably have a poor prognosis, and improved stratification of this heterogeneous group is needed. In th...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Elsevier
2018
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| _version_ | 1797104994746368000 |
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| author | Gonnissen, A Isebaert, S Perneel, C McKee, CM Van Utterbeeck, F Lerut, E Verrill, C Bryant, RJ Joniau, S Muschel, RJ Haustermans, K |
| author_facet | Gonnissen, A Isebaert, S Perneel, C McKee, CM Van Utterbeeck, F Lerut, E Verrill, C Bryant, RJ Joniau, S Muschel, RJ Haustermans, K |
| author_sort | Gonnissen, A |
| collection | OXFORD |
| description | There is an unmet clinical need for adequate biomarkers to aid risk stratification and management of prostate cancer (PCa) patients. Even within the high-risk PCa category not all patients will invariably have a poor prognosis, and improved stratification of this heterogeneous group is needed. In this context, components of the hedgehog (Hh) pathway may have promise as biomarkers, as the available evidence suggests increased Hh pathway activity may confer a poorer outcome in advanced and castrate-resistant PCa. In this study potential associations between Hh pathway protein expression and clinico-pathological factors, including time to biochemical recurrence (BCR), were investigated using a tissue microarray constructed from benign and malignant prostate samples from 75 predominantly high-risk PCa patients who underwent radical prostatectomy. Hh signaling activity was found to differ between benign and malignant prostate tissue, with a greater amount of active Hh signaling present in malignant than benign prostate epithelium. High expression of PTCH1 in malignant prostate epithelium was found to be an independent predictor of BCR in high-risk PCa patients. GLI1 may potentially represent a clinically useful biomarker of an aggressive tumor phenotype. Evaluation of Hh signaling activity in PCa patients may be useful for risk-stratification, and epithelial PTCH1 expression in particular may be a prognostic marker for BCR in high-risk PCa patients. |
| first_indexed | 2024-03-07T06:41:17Z |
| format | Journal article |
| id | oxford-uuid:f95d8484-acc5-453d-9a38-6bbb3851fd62 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:41:17Z |
| publishDate | 2018 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:f95d8484-acc5-453d-9a38-6bbb3851fd622022-03-27T12:57:28ZPatched 1 expression correlates with biochemical relapse in high-risk prostate cancer patientsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f95d8484-acc5-453d-9a38-6bbb3851fd62EnglishSymplectic Elements at OxfordElsevier2018Gonnissen, AIsebaert, SPerneel, CMcKee, CMVan Utterbeeck, FLerut, EVerrill, CBryant, RJJoniau, SMuschel, RJHaustermans, KThere is an unmet clinical need for adequate biomarkers to aid risk stratification and management of prostate cancer (PCa) patients. Even within the high-risk PCa category not all patients will invariably have a poor prognosis, and improved stratification of this heterogeneous group is needed. In this context, components of the hedgehog (Hh) pathway may have promise as biomarkers, as the available evidence suggests increased Hh pathway activity may confer a poorer outcome in advanced and castrate-resistant PCa. In this study potential associations between Hh pathway protein expression and clinico-pathological factors, including time to biochemical recurrence (BCR), were investigated using a tissue microarray constructed from benign and malignant prostate samples from 75 predominantly high-risk PCa patients who underwent radical prostatectomy. Hh signaling activity was found to differ between benign and malignant prostate tissue, with a greater amount of active Hh signaling present in malignant than benign prostate epithelium. High expression of PTCH1 in malignant prostate epithelium was found to be an independent predictor of BCR in high-risk PCa patients. GLI1 may potentially represent a clinically useful biomarker of an aggressive tumor phenotype. Evaluation of Hh signaling activity in PCa patients may be useful for risk-stratification, and epithelial PTCH1 expression in particular may be a prognostic marker for BCR in high-risk PCa patients. |
| spellingShingle | Gonnissen, A Isebaert, S Perneel, C McKee, CM Van Utterbeeck, F Lerut, E Verrill, C Bryant, RJ Joniau, S Muschel, RJ Haustermans, K Patched 1 expression correlates with biochemical relapse in high-risk prostate cancer patients |
| title | Patched 1 expression correlates with biochemical relapse in high-risk prostate cancer patients |
| title_full | Patched 1 expression correlates with biochemical relapse in high-risk prostate cancer patients |
| title_fullStr | Patched 1 expression correlates with biochemical relapse in high-risk prostate cancer patients |
| title_full_unstemmed | Patched 1 expression correlates with biochemical relapse in high-risk prostate cancer patients |
| title_short | Patched 1 expression correlates with biochemical relapse in high-risk prostate cancer patients |
| title_sort | patched 1 expression correlates with biochemical relapse in high risk prostate cancer patients |
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