Lateral pallidotomy exacerbates akinesia in the Parkinsonian patient.
Despite the recent resurgence of interest in the use of pallidotomy for the treatment of Parkinson's disease, there remains considerable debate about the optimal lesion site. Although the current understanding of the neural mechanisms underlying Parkinsonism would suggest that the medial pallid...
| Autori principali: | , , , , , , , |
|---|---|
| Natura: | Journal article |
| Lingua: | English |
| Pubblicazione: |
1999
|
| _version_ | 1826306001185275904 |
|---|---|
| author | Munro-Davies, L Gregory, R Squires, W Radatz, M Silburn, P Scott, R Aziz, T Stein, J |
| author_facet | Munro-Davies, L Gregory, R Squires, W Radatz, M Silburn, P Scott, R Aziz, T Stein, J |
| author_sort | Munro-Davies, L |
| collection | OXFORD |
| description | Despite the recent resurgence of interest in the use of pallidotomy for the treatment of Parkinson's disease, there remains considerable debate about the optimal lesion site. Although the current understanding of the neural mechanisms underlying Parkinsonism would suggest that the medial pallidum is the logical site for alleviation of symptoms, some surgeons still advocate lesions in the lateral pallidum. We report the case of such a lesion placement verified pathologically, which resulted in exacerbation of akinesia postoperatively. This demonstrates that accurate targeting in the pallidum is critical to avoid exacerbation of symptoms by lesioning the lateral pallidum. |
| first_indexed | 2024-03-07T06:41:18Z |
| format | Journal article |
| id | oxford-uuid:f95e8a15-012d-4c69-82a8-40e5abbc073e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:41:18Z |
| publishDate | 1999 |
| record_format | dspace |
| spelling | oxford-uuid:f95e8a15-012d-4c69-82a8-40e5abbc073e2022-03-27T12:57:33ZLateral pallidotomy exacerbates akinesia in the Parkinsonian patient.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f95e8a15-012d-4c69-82a8-40e5abbc073eEnglishSymplectic Elements at Oxford1999Munro-Davies, LGregory, RSquires, WRadatz, MSilburn, PScott, RAziz, TStein, JDespite the recent resurgence of interest in the use of pallidotomy for the treatment of Parkinson's disease, there remains considerable debate about the optimal lesion site. Although the current understanding of the neural mechanisms underlying Parkinsonism would suggest that the medial pallidum is the logical site for alleviation of symptoms, some surgeons still advocate lesions in the lateral pallidum. We report the case of such a lesion placement verified pathologically, which resulted in exacerbation of akinesia postoperatively. This demonstrates that accurate targeting in the pallidum is critical to avoid exacerbation of symptoms by lesioning the lateral pallidum. |
| spellingShingle | Munro-Davies, L Gregory, R Squires, W Radatz, M Silburn, P Scott, R Aziz, T Stein, J Lateral pallidotomy exacerbates akinesia in the Parkinsonian patient. |
| title | Lateral pallidotomy exacerbates akinesia in the Parkinsonian patient. |
| title_full | Lateral pallidotomy exacerbates akinesia in the Parkinsonian patient. |
| title_fullStr | Lateral pallidotomy exacerbates akinesia in the Parkinsonian patient. |
| title_full_unstemmed | Lateral pallidotomy exacerbates akinesia in the Parkinsonian patient. |
| title_short | Lateral pallidotomy exacerbates akinesia in the Parkinsonian patient. |
| title_sort | lateral pallidotomy exacerbates akinesia in the parkinsonian patient |
| work_keys_str_mv | AT munrodaviesl lateralpallidotomyexacerbatesakinesiaintheparkinsonianpatient AT gregoryr lateralpallidotomyexacerbatesakinesiaintheparkinsonianpatient AT squiresw lateralpallidotomyexacerbatesakinesiaintheparkinsonianpatient AT radatzm lateralpallidotomyexacerbatesakinesiaintheparkinsonianpatient AT silburnp lateralpallidotomyexacerbatesakinesiaintheparkinsonianpatient AT scottr lateralpallidotomyexacerbatesakinesiaintheparkinsonianpatient AT azizt lateralpallidotomyexacerbatesakinesiaintheparkinsonianpatient AT steinj lateralpallidotomyexacerbatesakinesiaintheparkinsonianpatient |