Lateral pallidotomy exacerbates akinesia in the Parkinsonian patient.

Despite the recent resurgence of interest in the use of pallidotomy for the treatment of Parkinson's disease, there remains considerable debate about the optimal lesion site. Although the current understanding of the neural mechanisms underlying Parkinsonism would suggest that the medial pallid...

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Main Authors: Munro-Davies, L, Gregory, R, Squires, W, Radatz, M, Silburn, P, Scott, R, Aziz, T, Stein, J
Formato: Journal article
Idioma:English
Publicado: 1999
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author Munro-Davies, L
Gregory, R
Squires, W
Radatz, M
Silburn, P
Scott, R
Aziz, T
Stein, J
author_facet Munro-Davies, L
Gregory, R
Squires, W
Radatz, M
Silburn, P
Scott, R
Aziz, T
Stein, J
author_sort Munro-Davies, L
collection OXFORD
description Despite the recent resurgence of interest in the use of pallidotomy for the treatment of Parkinson's disease, there remains considerable debate about the optimal lesion site. Although the current understanding of the neural mechanisms underlying Parkinsonism would suggest that the medial pallidum is the logical site for alleviation of symptoms, some surgeons still advocate lesions in the lateral pallidum. We report the case of such a lesion placement verified pathologically, which resulted in exacerbation of akinesia postoperatively. This demonstrates that accurate targeting in the pallidum is critical to avoid exacerbation of symptoms by lesioning the lateral pallidum.
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spelling oxford-uuid:f95e8a15-012d-4c69-82a8-40e5abbc073e2022-03-27T12:57:33ZLateral pallidotomy exacerbates akinesia in the Parkinsonian patient.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f95e8a15-012d-4c69-82a8-40e5abbc073eEnglishSymplectic Elements at Oxford1999Munro-Davies, LGregory, RSquires, WRadatz, MSilburn, PScott, RAziz, TStein, JDespite the recent resurgence of interest in the use of pallidotomy for the treatment of Parkinson's disease, there remains considerable debate about the optimal lesion site. Although the current understanding of the neural mechanisms underlying Parkinsonism would suggest that the medial pallidum is the logical site for alleviation of symptoms, some surgeons still advocate lesions in the lateral pallidum. We report the case of such a lesion placement verified pathologically, which resulted in exacerbation of akinesia postoperatively. This demonstrates that accurate targeting in the pallidum is critical to avoid exacerbation of symptoms by lesioning the lateral pallidum.
spellingShingle Munro-Davies, L
Gregory, R
Squires, W
Radatz, M
Silburn, P
Scott, R
Aziz, T
Stein, J
Lateral pallidotomy exacerbates akinesia in the Parkinsonian patient.
title Lateral pallidotomy exacerbates akinesia in the Parkinsonian patient.
title_full Lateral pallidotomy exacerbates akinesia in the Parkinsonian patient.
title_fullStr Lateral pallidotomy exacerbates akinesia in the Parkinsonian patient.
title_full_unstemmed Lateral pallidotomy exacerbates akinesia in the Parkinsonian patient.
title_short Lateral pallidotomy exacerbates akinesia in the Parkinsonian patient.
title_sort lateral pallidotomy exacerbates akinesia in the parkinsonian patient
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