Pharmacokinetics of oral doxycycline during combination treatment of severe falciparum malaria.
The pharmacokinetics of oral doxycycline administered at 200 mg every 24 h were investigated in 17 patients recovering from severe Plasmodium falciparum malaria. The data suggest that the doses of doxycycline currently recommended (circa 3.5 mg/kg of body weight daily) may not be optimal.
Autori principali: | Newton, P, Chaulet, J, Brockman, A, Chierakul, W, Dondorp, A, Ruangveerayuth, R, Looareesuwan, S, Mounier, C, White, N |
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Natura: | Journal article |
Lingua: | English |
Pubblicazione: |
2005
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