Elevated cortical glutamate in young people at increased familial risk of depression.
Using proton magnetic resonance spectroscopy (MRS), we have demonstrated regional abnormalities in cortical γ-aminobutyric acid (GABA) and glutamate in medication-free recovered depressed patients. It is unclear whether these changes represent an underlying trait vulnerability to depression, or an a...
| Glavni autori: | , , , , |
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| Format: | Journal article |
| Jezik: | English |
| Izdano: |
2011
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| _version_ | 1826306032644653056 |
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| author | Taylor, M Mannie, Z Norbury, R Near, J Cowen, P |
| author_facet | Taylor, M Mannie, Z Norbury, R Near, J Cowen, P |
| author_sort | Taylor, M |
| collection | OXFORD |
| description | Using proton magnetic resonance spectroscopy (MRS), we have demonstrated regional abnormalities in cortical γ-aminobutyric acid (GABA) and glutamate in medication-free recovered depressed patients. It is unclear whether these changes represent an underlying trait vulnerability to depression, or an after-effect of episodes of illness or its treatment. We sought to examine this question by examining a group of high-risk, never-depressed, individuals. We used MRS to measure GABA and glutamate in parieto-occipital cortex in young people (ages 16-21 yr) with a family history of parental depression (n=24) but no personal history of illness and a control group without a history of depression in any first-degree relative (n=28). Participants with a parental history of depression had significantly higher levels of glutamate than controls in parieto-occipital cortex (F₁,₄₇=5.5, p=0.02). These findings suggest that abnormalities in glutamate neurotransmission may reflect a trait marker of vulnerability to depression. |
| first_indexed | 2024-03-07T06:41:47Z |
| format | Journal article |
| id | oxford-uuid:f987bc14-250f-44bc-9b57-59450a98fc95 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:41:47Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:f987bc14-250f-44bc-9b57-59450a98fc952022-03-27T12:58:36ZElevated cortical glutamate in young people at increased familial risk of depression.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f987bc14-250f-44bc-9b57-59450a98fc95EnglishSymplectic Elements at Oxford2011Taylor, MMannie, ZNorbury, RNear, JCowen, PUsing proton magnetic resonance spectroscopy (MRS), we have demonstrated regional abnormalities in cortical γ-aminobutyric acid (GABA) and glutamate in medication-free recovered depressed patients. It is unclear whether these changes represent an underlying trait vulnerability to depression, or an after-effect of episodes of illness or its treatment. We sought to examine this question by examining a group of high-risk, never-depressed, individuals. We used MRS to measure GABA and glutamate in parieto-occipital cortex in young people (ages 16-21 yr) with a family history of parental depression (n=24) but no personal history of illness and a control group without a history of depression in any first-degree relative (n=28). Participants with a parental history of depression had significantly higher levels of glutamate than controls in parieto-occipital cortex (F₁,₄₇=5.5, p=0.02). These findings suggest that abnormalities in glutamate neurotransmission may reflect a trait marker of vulnerability to depression. |
| spellingShingle | Taylor, M Mannie, Z Norbury, R Near, J Cowen, P Elevated cortical glutamate in young people at increased familial risk of depression. |
| title | Elevated cortical glutamate in young people at increased familial risk of depression. |
| title_full | Elevated cortical glutamate in young people at increased familial risk of depression. |
| title_fullStr | Elevated cortical glutamate in young people at increased familial risk of depression. |
| title_full_unstemmed | Elevated cortical glutamate in young people at increased familial risk of depression. |
| title_short | Elevated cortical glutamate in young people at increased familial risk of depression. |
| title_sort | elevated cortical glutamate in young people at increased familial risk of depression |
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