A genome-wide association study based on the China Kadoorie Biobank identifies genetic associations between snoring and cardiometabolic traits
Despite the high prevalence of snoring in Asia, little is known about the genetic etiology of snoring and its causal relationships with cardiometabolic traits. Based on 100,626 Chinese individuals, a genome-wide association study on snoring was conducted. Four novel loci were identified for snoring...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Outros autores: | |
| Formato: | Journal article |
| Idioma: | English |
| Publicado: |
Springer Nature
2024
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| _version_ | 1826312615744241664 |
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| author | Zhu, Y Zhuang, Z Lv, J Sun, D Pei, P Yang, L Millwood, IY Walters, RG Chen, Y Du, H Liu, F Stevens, R Chen, J Chen, Z Li, L Yu, C |
| author2 | China Kadoorie Biobank Collaborative Group |
| author_facet | China Kadoorie Biobank Collaborative Group Zhu, Y Zhuang, Z Lv, J Sun, D Pei, P Yang, L Millwood, IY Walters, RG Chen, Y Du, H Liu, F Stevens, R Chen, J Chen, Z Li, L Yu, C |
| author_sort | Zhu, Y |
| collection | OXFORD |
| description | Despite the high prevalence of snoring in Asia, little is known about the genetic etiology of snoring and its causal relationships with cardiometabolic traits. Based on 100,626 Chinese individuals, a genome-wide association study on snoring was conducted. Four novel loci were identified for snoring traits mapped on SLC25A21, the intergenic region of WDR11 and FGFR, NAA25, ALDH2, and VTI1A, respectively. The novel loci highlighted the roles of structural abnormality of the upper airway and craniofacial region and dysfunction of metabolic and transport systems in the development of snoring. In the two-sample bi-directional Mendelian randomization analysis, higher body mass index, weight, and elevated blood pressure were causal for snoring, and a reverse causal effect was observed between snoring and diastolic blood pressure. Altogether, our results revealed the possible etiology of snoring in China and indicated that managing cardiometabolic health was essential to snoring prevention, and hypertension should be considered among snorers. |
| first_indexed | 2024-04-09T03:55:39Z |
| format | Journal article |
| id | oxford-uuid:f987c791-6168-4b0c-badd-8c3089d1c042 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-04-09T03:55:39Z |
| publishDate | 2024 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:f987c791-6168-4b0c-badd-8c3089d1c0422024-03-12T16:44:59ZA genome-wide association study based on the China Kadoorie Biobank identifies genetic associations between snoring and cardiometabolic traitsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f987c791-6168-4b0c-badd-8c3089d1c042EnglishSymplectic ElementsSpringer Nature2024Zhu, YZhuang, ZLv, JSun, DPei, PYang, LMillwood, IYWalters, RGChen, YDu, HLiu, FStevens, RChen, JChen, ZLi, LYu, CChina Kadoorie Biobank Collaborative GroupDespite the high prevalence of snoring in Asia, little is known about the genetic etiology of snoring and its causal relationships with cardiometabolic traits. Based on 100,626 Chinese individuals, a genome-wide association study on snoring was conducted. Four novel loci were identified for snoring traits mapped on SLC25A21, the intergenic region of WDR11 and FGFR, NAA25, ALDH2, and VTI1A, respectively. The novel loci highlighted the roles of structural abnormality of the upper airway and craniofacial region and dysfunction of metabolic and transport systems in the development of snoring. In the two-sample bi-directional Mendelian randomization analysis, higher body mass index, weight, and elevated blood pressure were causal for snoring, and a reverse causal effect was observed between snoring and diastolic blood pressure. Altogether, our results revealed the possible etiology of snoring in China and indicated that managing cardiometabolic health was essential to snoring prevention, and hypertension should be considered among snorers. |
| spellingShingle | Zhu, Y Zhuang, Z Lv, J Sun, D Pei, P Yang, L Millwood, IY Walters, RG Chen, Y Du, H Liu, F Stevens, R Chen, J Chen, Z Li, L Yu, C A genome-wide association study based on the China Kadoorie Biobank identifies genetic associations between snoring and cardiometabolic traits |
| title | A genome-wide association study based on the China Kadoorie Biobank identifies genetic associations between snoring and cardiometabolic traits |
| title_full | A genome-wide association study based on the China Kadoorie Biobank identifies genetic associations between snoring and cardiometabolic traits |
| title_fullStr | A genome-wide association study based on the China Kadoorie Biobank identifies genetic associations between snoring and cardiometabolic traits |
| title_full_unstemmed | A genome-wide association study based on the China Kadoorie Biobank identifies genetic associations between snoring and cardiometabolic traits |
| title_short | A genome-wide association study based on the China Kadoorie Biobank identifies genetic associations between snoring and cardiometabolic traits |
| title_sort | genome wide association study based on the china kadoorie biobank identifies genetic associations between snoring and cardiometabolic traits |
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