Major histocompatibility complex class II antigen expression in nerves in leprosy; an immunoelectronmicroscopical study.
A technique for immunoelectronmicroscopy has been used to investigate major histocompatibility class II expression in leprosy nerves. In normal nerves, endothelial cells and occasional endoneural cells (not Schwann cells) were constitutively class II positive. In both paucibacillary and multibacilla...
| Main Authors: | , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
1990
|
| _version_ | 1797105043664535552 |
|---|---|
| author | Cowley, S Gschmeissner, SE Negesse, Y Curtis, J Turk, J |
| author_facet | Cowley, S Gschmeissner, SE Negesse, Y Curtis, J Turk, J |
| author_sort | Cowley, S |
| collection | OXFORD |
| description | A technique for immunoelectronmicroscopy has been used to investigate major histocompatibility class II expression in leprosy nerves. In normal nerves, endothelial cells and occasional endoneural cells (not Schwann cells) were constitutively class II positive. In both paucibacillary and multibacillary leprosy nerve biopsies, infiltrating leukocytes were positive but class II-positive Schwann cells were not seen. These observations indicate that Schwann cells may not be involved in presenting Mycobacterium leprae antigens to T cells in leprosy. This conflicts with evidence from in vitro studies, but may be explained by the fact that in vivo Schwann cells are surrounded by basement membranes and are closely associated with axons. |
| first_indexed | 2024-03-07T06:41:55Z |
| format | Journal article |
| id | oxford-uuid:f9948b59-d2a6-493b-b692-fa409a2f721a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:41:55Z |
| publishDate | 1990 |
| record_format | dspace |
| spelling | oxford-uuid:f9948b59-d2a6-493b-b692-fa409a2f721a2022-03-27T12:59:01ZMajor histocompatibility complex class II antigen expression in nerves in leprosy; an immunoelectronmicroscopical study.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f9948b59-d2a6-493b-b692-fa409a2f721aEnglishSymplectic Elements at Oxford1990Cowley, SGschmeissner, SENegesse, YCurtis, JTurk, JA technique for immunoelectronmicroscopy has been used to investigate major histocompatibility class II expression in leprosy nerves. In normal nerves, endothelial cells and occasional endoneural cells (not Schwann cells) were constitutively class II positive. In both paucibacillary and multibacillary leprosy nerve biopsies, infiltrating leukocytes were positive but class II-positive Schwann cells were not seen. These observations indicate that Schwann cells may not be involved in presenting Mycobacterium leprae antigens to T cells in leprosy. This conflicts with evidence from in vitro studies, but may be explained by the fact that in vivo Schwann cells are surrounded by basement membranes and are closely associated with axons. |
| spellingShingle | Cowley, S Gschmeissner, SE Negesse, Y Curtis, J Turk, J Major histocompatibility complex class II antigen expression in nerves in leprosy; an immunoelectronmicroscopical study. |
| title | Major histocompatibility complex class II antigen expression in nerves in leprosy; an immunoelectronmicroscopical study. |
| title_full | Major histocompatibility complex class II antigen expression in nerves in leprosy; an immunoelectronmicroscopical study. |
| title_fullStr | Major histocompatibility complex class II antigen expression in nerves in leprosy; an immunoelectronmicroscopical study. |
| title_full_unstemmed | Major histocompatibility complex class II antigen expression in nerves in leprosy; an immunoelectronmicroscopical study. |
| title_short | Major histocompatibility complex class II antigen expression in nerves in leprosy; an immunoelectronmicroscopical study. |
| title_sort | major histocompatibility complex class ii antigen expression in nerves in leprosy an immunoelectronmicroscopical study |
| work_keys_str_mv | AT cowleys majorhistocompatibilitycomplexclassiiantigenexpressioninnervesinleprosyanimmunoelectronmicroscopicalstudy AT gschmeissnerse majorhistocompatibilitycomplexclassiiantigenexpressioninnervesinleprosyanimmunoelectronmicroscopicalstudy AT negessey majorhistocompatibilitycomplexclassiiantigenexpressioninnervesinleprosyanimmunoelectronmicroscopicalstudy AT curtisj majorhistocompatibilitycomplexclassiiantigenexpressioninnervesinleprosyanimmunoelectronmicroscopicalstudy AT turkj majorhistocompatibilitycomplexclassiiantigenexpressioninnervesinleprosyanimmunoelectronmicroscopicalstudy |