Dopamine enhances willingness to exert effort for reward in Parkinson's disease.

Dopamine enhances willingness to exert effort for reward in Parkinson's disease.

Parkinson's disease (PD) is traditionally conceptualised as a disorder of movement, but recent data suggest that motivational deficits may be more pervasive than previously thought. Here, we ask whether subclinical deficits in incentivised decision-making are present in PD and, if so, whether d...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Chong, T, Bonnelle, V, Manohar, S, Veromann, K, Muhammed, K, Tofaris, G, Hu, M, Husain, M
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	Elsevier 2015

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Dissociation of reward and effort sensitivity in methcathinone-induced Parkinsonism
gan: Chong, T, et al.
Cyhoeddwyd: (2017)

Reward sensitivity deficits modulated by dopamine are associated with apathy in Parkinson's disease.
gan: Muhammed, K, et al.
Cyhoeddwyd: (2016)

Characterization of reward and effort mechanisms in apathy.
gan: Bonnelle, V, et al.
Cyhoeddwyd: (2015)

Dopamine and reward hypersensitivity in Parkinson's disease with impulse control disorder
gan: Drew, DS, et al.
Cyhoeddwyd: (2020)

Reward sensitivity deficits underlie apathy in Parkinson's disease
gan: Muhammed, K, et al.
Cyhoeddwyd: (2015)

Distinct effects of apathy and dopamine on effort-based decision making in Parkinson’s disease
gan: Le Heron, C, et al.
Cyhoeddwyd: (2018)

Reward sensitivity and action in Parkinson’s disease patients with and without apathy
gan: Muhammed, K, et al.
Cyhoeddwyd: (2021)

Reduced pupillary reward sensitivity in Parkinson’s disease
gan: Manohar, S, et al.
Cyhoeddwyd: (2015)

Fractionating the neurocognitive mechanisms underlying working memory: independent effects of dopamine and Parkinson’s disease
gan: Fallon, S, et al.
Cyhoeddwyd: (2017)

Commentary: Noradrenaline and dopamine neurons in the reward/effort trade-off: a direct electrophysiological comparison in behaving monkeys
gan: Ang, Y, et al.
Cyhoeddwyd: (2015)

The role of cognitive effort in subjective reward devaluation and risky decision-making
gan: Apps, M, et al.
Cyhoeddwyd: (2015)

Dopamine promotes instrumental motivation, but reduces reward-related vigour
gan: Grogan, JP, et al.
Cyhoeddwyd: (2020)

Dopamine modulates option generation for behaviour
gan: Ang, Y, et al.
Cyhoeddwyd: (2018)

Clinical significance of apathy in Parkinson's disease
gan: Muhammed, K, et al.
Cyhoeddwyd: (2016)

Missed rewards capture attention
gan: Manohar, S, et al.
Cyhoeddwyd: (2012)

What is the relationship between dopamine and effort?
gan: Walton, M, et al.
Cyhoeddwyd: (2018)

Impulsivity and apathy in Parkinson's disease
gan: Sinha, N, et al.
Cyhoeddwyd: (2013)

Brain mechanisms underlying fatigue and its impact on the motivation to exert effort
gan: Müller, T
Cyhoeddwyd: (2021)

Dopamine affects short-term memory corruption over time in Parkinson's disease
gan: Fallon, SJ, et al.
Cyhoeddwyd: (2019)

Motivational fatigue: a neurocognitive framework for the impact of effortful exertion on subsequent motivation
gan: Müller, T, et al.
Cyhoeddwyd: (2018)

Dopamine and reward : effects of dopamine antagonist drugs on operant and consummatory behaviours
gan: Phillips, Gavin
Cyhoeddwyd: (1990)

α-Synuclein and dopamine at the crossroads of Parkinson's disease.
gan: Venda, L, et al.
Cyhoeddwyd: (2010)

Dopamine reverses reward insensitivity in apathy following globus pallidus lesions
gan: Adam, R, et al.
Cyhoeddwyd: (2013)

Dopamine reverses reward insensitivity in apathy following globus pallidus lesions.
gan: Adam, R, et al.
Cyhoeddwyd: (2013)

Dopamine guides competition for cognitive control: common effects of haloperidol on working memory and response conflict
gan: Fallon, S, et al.
Cyhoeddwyd: (2018)

Human ventromedial prefrontal lesions alter incentivisation by reward
gan: Manohar, S, et al.
Cyhoeddwyd: (2016)

IS DOPAMINE NECESSARY FOR ELECTRICAL BRAIN-STIMULATION TO BE REWARDING
gan: Fray, P, et al.
Cyhoeddwyd: (1977)

Nicotine amplifies reward-related dopamine signals in striatum.
gan: Rice, M, et al.
Cyhoeddwyd: (2004)

Striatal acetylcholine control of reward-related dopamine signalling
gan: Cragg, S, et al.
Cyhoeddwyd: (2005)

Layered reward signalling through octopamine and dopamine in Drosophila
gan: Burke, C, et al.
Cyhoeddwyd: (2012)

Layered reward signalling through octopamine and dopamine in Drosophila
gan: Burke, C, et al.
Cyhoeddwyd: (2012)

Effects of dopamine on reinforcement learning and consolidation in Parkinson’s disease
gan: Grogan, J, et al.
Cyhoeddwyd: (2017)

Dopamine agonists and risk: impulse control disorders in Parkinson's disease.
gan: Voon, V, et al.
Cyhoeddwyd: (2011)

Dopamine agonists and risk: Impulse control disorders in Parkinson's; Disease
gan: Voon, V, et al.
Cyhoeddwyd: (2011)

Effort but not reward sensitivity is altered by acute sickness induced by experimental endotoxemia in humans
gan: Draper, A, et al.
Cyhoeddwyd: (2017)

Past rewards capture spatial attention and action choices.
gan: Camara, E, et al.
Cyhoeddwyd: (2013)

Past rewards capture spatial attention and action choices
gan: Camara, E, et al.
Cyhoeddwyd: (2013)

Dopamine Ramps Are a Consequence of Reward Prediction Errors
gan: Gershman, Samuel J.
Cyhoeddwyd: (2014)

Dissociable cost and benefit encoding of future rewards by mesolimbic dopamine.
gan: Gan, J, et al.
Cyhoeddwyd: (2010)

Initiation and progression of α-synuclein pathology in Parkinson’s disease
gan: Tofaris, GK
Cyhoeddwyd: (2022)