Sickle erythrocytes target cytotoxics to hypoxic tumor microvessels and potentiate a tumoricidal response
Resistance of hypoxic solid tumor niches to chemotherapy and radiotherapy remains a major scientific challenge that calls for conceptually new approaches. Here we exploit a hitherto unrecognized ability of sickled erythrocytes (SSRBCs) but not normal RBCs (NLRBCs) to selectively target hypoxic tumor...
Main Authors: | Terman, DS, Viglianti, BL, Zennadi, R, Fels, D, Boruta, RJ, Yuan, H, Dreher, MR, Grant, G, Rabbani, ZN, Moon, EJ, Lan, L, Eble, J, Cao, Y, Sorg, B, Ashcraft, K, Palmer, G, Telen, MJ, Dewhirst, MW |
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Format: | Journal article |
Language: | English |
Published: |
Public Library of Science
2013
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