A checkpoint cliffhanger at the dawn of placental mammals

The PD-1 ligands PD-L1 and PD-L2 are commonly expressed on the surface of cells, where they regulate immune system activation. However, the specific role played by each ligand has been unclear. Using site-directed mutagenesis, surface plasmon resonance, and crystallography, Philips et al. explore th...

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Main Authors: Dustin, ML, Zenclussen, AC
Format: Journal article
Language:English
Published: American Society for Biochemistry and Molecular Biology 2020
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author Dustin, ML
Zenclussen, AC
author_facet Dustin, ML
Zenclussen, AC
author_sort Dustin, ML
collection OXFORD
description The PD-1 ligands PD-L1 and PD-L2 are commonly expressed on the surface of cells, where they regulate immune system activation. However, the specific role played by each ligand has been unclear. Using site-directed mutagenesis, surface plasmon resonance, and crystallography, Philips et al. explore the distinct features of PD-L2 and identify a specific evolutionary event linked to its appearance. This work provides a deeper understanding of how the immune system adapted to mammalian placental gestation and could be an important consideration in the development of new immune checkpoint therapies.
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spelling oxford-uuid:f9ed179b-6f7e-43de-b7f1-31bf47d235452022-03-27T13:01:42ZA checkpoint cliffhanger at the dawn of placental mammalsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f9ed179b-6f7e-43de-b7f1-31bf47d23545EnglishSymplectic ElementsAmerican Society for Biochemistry and Molecular Biology2020Dustin, MLZenclussen, ACThe PD-1 ligands PD-L1 and PD-L2 are commonly expressed on the surface of cells, where they regulate immune system activation. However, the specific role played by each ligand has been unclear. Using site-directed mutagenesis, surface plasmon resonance, and crystallography, Philips et al. explore the distinct features of PD-L2 and identify a specific evolutionary event linked to its appearance. This work provides a deeper understanding of how the immune system adapted to mammalian placental gestation and could be an important consideration in the development of new immune checkpoint therapies.
spellingShingle Dustin, ML
Zenclussen, AC
A checkpoint cliffhanger at the dawn of placental mammals
title A checkpoint cliffhanger at the dawn of placental mammals
title_full A checkpoint cliffhanger at the dawn of placental mammals
title_fullStr A checkpoint cliffhanger at the dawn of placental mammals
title_full_unstemmed A checkpoint cliffhanger at the dawn of placental mammals
title_short A checkpoint cliffhanger at the dawn of placental mammals
title_sort checkpoint cliffhanger at the dawn of placental mammals
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AT zenclussenac acheckpointcliffhangeratthedawnofplacentalmammals
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