A checkpoint cliffhanger at the dawn of placental mammals
The PD-1 ligands PD-L1 and PD-L2 are commonly expressed on the surface of cells, where they regulate immune system activation. However, the specific role played by each ligand has been unclear. Using site-directed mutagenesis, surface plasmon resonance, and crystallography, Philips et al. explore th...
Main Authors: | , |
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Format: | Journal article |
Language: | English |
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American Society for Biochemistry and Molecular Biology
2020
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_version_ | 1797105120144523264 |
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author | Dustin, ML Zenclussen, AC |
author_facet | Dustin, ML Zenclussen, AC |
author_sort | Dustin, ML |
collection | OXFORD |
description | The PD-1 ligands PD-L1 and PD-L2 are commonly expressed on the surface of cells, where they regulate immune system activation. However, the specific role played by each ligand has been unclear. Using site-directed mutagenesis, surface plasmon resonance, and crystallography, Philips et al. explore the distinct features of PD-L2 and identify a specific evolutionary event linked to its appearance. This work provides a deeper understanding of how the immune system adapted to mammalian placental gestation and could be an important consideration in the development of new immune checkpoint therapies. |
first_indexed | 2024-03-07T06:42:59Z |
format | Journal article |
id | oxford-uuid:f9ed179b-6f7e-43de-b7f1-31bf47d23545 |
institution | University of Oxford |
language | English |
last_indexed | 2024-03-07T06:42:59Z |
publishDate | 2020 |
publisher | American Society for Biochemistry and Molecular Biology |
record_format | dspace |
spelling | oxford-uuid:f9ed179b-6f7e-43de-b7f1-31bf47d235452022-03-27T13:01:42ZA checkpoint cliffhanger at the dawn of placental mammalsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f9ed179b-6f7e-43de-b7f1-31bf47d23545EnglishSymplectic ElementsAmerican Society for Biochemistry and Molecular Biology2020Dustin, MLZenclussen, ACThe PD-1 ligands PD-L1 and PD-L2 are commonly expressed on the surface of cells, where they regulate immune system activation. However, the specific role played by each ligand has been unclear. Using site-directed mutagenesis, surface plasmon resonance, and crystallography, Philips et al. explore the distinct features of PD-L2 and identify a specific evolutionary event linked to its appearance. This work provides a deeper understanding of how the immune system adapted to mammalian placental gestation and could be an important consideration in the development of new immune checkpoint therapies. |
spellingShingle | Dustin, ML Zenclussen, AC A checkpoint cliffhanger at the dawn of placental mammals |
title | A checkpoint cliffhanger at the dawn of placental mammals |
title_full | A checkpoint cliffhanger at the dawn of placental mammals |
title_fullStr | A checkpoint cliffhanger at the dawn of placental mammals |
title_full_unstemmed | A checkpoint cliffhanger at the dawn of placental mammals |
title_short | A checkpoint cliffhanger at the dawn of placental mammals |
title_sort | checkpoint cliffhanger at the dawn of placental mammals |
work_keys_str_mv | AT dustinml acheckpointcliffhangeratthedawnofplacentalmammals AT zenclussenac acheckpointcliffhangeratthedawnofplacentalmammals AT dustinml checkpointcliffhangeratthedawnofplacentalmammals AT zenclussenac checkpointcliffhangeratthedawnofplacentalmammals |