One-year clinical outcomes after sirolimus-eluting coronary stent implantation for acute myocardial infarction in the worldwide e-SELECT registry
Background: The aim was to ascertain the 1-year clinical outcomes of 1,234 patients who underwent implantations of sirolimus-eluting stents (SES) for acute myocardial infarction (MI) in the multinational e-SELECT registry. Methods: Fifteen thousand and one hundred and forty-seven patients treated wi...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2012
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| _version_ | 1797105121585266688 |
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| author | Worthley, S Abizaid, A Banning, A Bartorelli, A Džavík, V Ellis, S Gao, R Legrand, V Urban, P Spaulding, C |
| author_facet | Worthley, S Abizaid, A Banning, A Bartorelli, A Džavík, V Ellis, S Gao, R Legrand, V Urban, P Spaulding, C |
| author_sort | Worthley, S |
| collection | OXFORD |
| description | Background: The aim was to ascertain the 1-year clinical outcomes of 1,234 patients who underwent implantations of sirolimus-eluting stents (SES) for acute myocardial infarction (MI) in the multinational e-SELECT registry. Methods: Fifteen thousand and one hundred and forty-seven patients treated with SES were entered in the e-SELECT registry, of whom 1,234 presented within <24 hours of onset of acute MI. Results: At 1 year, the rates of major adverse cardiac events (MACE) (5.5% vs. 4.8%; P = 0.28) were similarly low in the acute and no acute MI groups. The rates of definite/probable stent thrombosis (ST) were higher in the acute MI group (2.1%vs; 0.88%, P < 0.001). ST was a strong independent predictor of death at 1 year (HR 13.4; 95% CI 5.0, 36.0; P < 0.001) and MI (HR 58.9; 95% CI 26.9, 129.1; P < 0.001). Dual antiplatelet therapy (DAPT) compliance at 6 months was 96.0% in the acute MI versus 94.5% in the no acute MI group (P = 0.03). Conclusion: In selected patients presenting within <24 hours of acute MI onset and highly compliant with DAPT, SES implantation was associated with similar rates of MACE, though higher rates of ST, as compared to no acute MI patients. ©2012, Wiley Periodicals, Inc. |
| first_indexed | 2024-03-07T06:43:01Z |
| format | Journal article |
| id | oxford-uuid:f9ef0252-59d8-47ac-ab45-0953837a4fb3 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:43:01Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:f9ef0252-59d8-47ac-ab45-0953837a4fb32022-03-27T13:01:47ZOne-year clinical outcomes after sirolimus-eluting coronary stent implantation for acute myocardial infarction in the worldwide e-SELECT registryJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f9ef0252-59d8-47ac-ab45-0953837a4fb3EnglishSymplectic Elements at Oxford2012Worthley, SAbizaid, ABanning, ABartorelli, ADžavík, VEllis, SGao, RLegrand, VUrban, PSpaulding, CBackground: The aim was to ascertain the 1-year clinical outcomes of 1,234 patients who underwent implantations of sirolimus-eluting stents (SES) for acute myocardial infarction (MI) in the multinational e-SELECT registry. Methods: Fifteen thousand and one hundred and forty-seven patients treated with SES were entered in the e-SELECT registry, of whom 1,234 presented within <24 hours of onset of acute MI. Results: At 1 year, the rates of major adverse cardiac events (MACE) (5.5% vs. 4.8%; P = 0.28) were similarly low in the acute and no acute MI groups. The rates of definite/probable stent thrombosis (ST) were higher in the acute MI group (2.1%vs; 0.88%, P < 0.001). ST was a strong independent predictor of death at 1 year (HR 13.4; 95% CI 5.0, 36.0; P < 0.001) and MI (HR 58.9; 95% CI 26.9, 129.1; P < 0.001). Dual antiplatelet therapy (DAPT) compliance at 6 months was 96.0% in the acute MI versus 94.5% in the no acute MI group (P = 0.03). Conclusion: In selected patients presenting within <24 hours of acute MI onset and highly compliant with DAPT, SES implantation was associated with similar rates of MACE, though higher rates of ST, as compared to no acute MI patients. ©2012, Wiley Periodicals, Inc. |
| spellingShingle | Worthley, S Abizaid, A Banning, A Bartorelli, A Džavík, V Ellis, S Gao, R Legrand, V Urban, P Spaulding, C One-year clinical outcomes after sirolimus-eluting coronary stent implantation for acute myocardial infarction in the worldwide e-SELECT registry |
| title | One-year clinical outcomes after sirolimus-eluting coronary stent implantation for acute myocardial infarction in the worldwide e-SELECT registry |
| title_full | One-year clinical outcomes after sirolimus-eluting coronary stent implantation for acute myocardial infarction in the worldwide e-SELECT registry |
| title_fullStr | One-year clinical outcomes after sirolimus-eluting coronary stent implantation for acute myocardial infarction in the worldwide e-SELECT registry |
| title_full_unstemmed | One-year clinical outcomes after sirolimus-eluting coronary stent implantation for acute myocardial infarction in the worldwide e-SELECT registry |
| title_short | One-year clinical outcomes after sirolimus-eluting coronary stent implantation for acute myocardial infarction in the worldwide e-SELECT registry |
| title_sort | one year clinical outcomes after sirolimus eluting coronary stent implantation for acute myocardial infarction in the worldwide e select registry |
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