Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation
Atrial fibrillation affects more than 33 million people worldwide and increases the risk of stroke, heart failure, and death. Fourteen genetic loci have been associated with atrial fibrillation in European and Asian ancestry groups. To further define the genetic basis of atrial fibrillation, we perf...
| Автори: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Формат: | Journal article |
| Мова: | English |
| Опубліковано: |
Springer Nature
2017
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| _version_ | 1826306121252470784 |
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| author | Christophersen, IE Rienstra, M Roselli, C Yin, X Geelhoed, B Barnard, J Lin, H Arking, DE Smith, AV Albert, CM Chaffin, M Tucker, NR Li, M Klarin, D Bihlmeyer, NA Low, SK Weeke, PE Müller-Nurasyid, M Smith, JG Brody, JA Niemeijer, MN Dörr, M Trompet, S Huffman, J Gustafsson, S Schurmann, C Kleber, ME Lyytikäinen, LP Seppälä, I Malik, R Horimoto, ARVR Perez, M Sinisalo, J Aeschbacher, S Thériault, S Yao, J Radmanesh, F Weiss, S Teumer, A Choi, SH Weng, LC Clauss, S Deo, R Rader, DJ Shah, SH Sun, A Hopewell, JC Debette, S Chauhan, G Yang, Q Worrall, BB Paré, G Kamatani, Y Hagemeijer, YP Verweij, N Siland, JE Kubo, M Smith, JD Van Wagoner, DR Bis, JC Perz, S Psaty, BM Ridker, PM Magnani, JW Harris, TB Launer, LJ Shoemaker, MB Padmanabhan, S Haessler, J Bartz, TM Waldenberger, M Lichtner, P Arendt, M Krieger, JE Kähönen, M Risch, L Mansur, AJ Peters, A Smith, BH Lind, L Scott, SA Lu, Y Bottinger, EB Hernesniemi, J Lindgren, CM Wong, JA Huang, J Eskola, M Morris, AP Ford, I Reiner, AP Delgado, G Chen, LY Chen, YI Sandhu, RK Li, M Boerwinkle, E Eisele, L Lannfelt, L Rost, N Anderson, CD Taylor, KD Campbell, A Magnusson, PK Porteous, D Hocking, LJ Vlachopoulou, E Pedersen, NL Nikus, K Orho-Melander, M Hamsten, A Heeringa, J Denny, JC Kriebel, J Darbar, D Newton-Cheh, C Shaffer, C Macfarlane, PW Heilmann-Heimbach, S Almgren, P Huang, PL Sotoodehnia, N Soliman, EZ Uitterlinden, AG Hofman, A Franco, OH Völker, U Jöckel, KH Sinner, MF Lin, HJ Guo, X METASTROKE Consortium of the ISGC, Neurology Working Group of the CHARGE Consortium, Dichgans, M Ingelsson, E Kooperberg, C Melander, O Loos, RJF Laurikka, J Conen, D Rosand, J van der Harst, P Lokki, ML Kathiresan, S Pereira, A Jukema, JW Hayward, C Rotter, JI März, W Lehtimäki, T Stricker, BH Chung, MK Felix, SB Gudnason, V Alonso, A Roden, DM Kääb, S Chasman, DI Heckbert, SR Benjamin, EJ Tanaka, T Lunetta, KL Lubitz, SA Ellinor, PT AFGen Consortium |
| author_facet | Christophersen, IE Rienstra, M Roselli, C Yin, X Geelhoed, B Barnard, J Lin, H Arking, DE Smith, AV Albert, CM Chaffin, M Tucker, NR Li, M Klarin, D Bihlmeyer, NA Low, SK Weeke, PE Müller-Nurasyid, M Smith, JG Brody, JA Niemeijer, MN Dörr, M Trompet, S Huffman, J Gustafsson, S Schurmann, C Kleber, ME Lyytikäinen, LP Seppälä, I Malik, R Horimoto, ARVR Perez, M Sinisalo, J Aeschbacher, S Thériault, S Yao, J Radmanesh, F Weiss, S Teumer, A Choi, SH Weng, LC Clauss, S Deo, R Rader, DJ Shah, SH Sun, A Hopewell, JC Debette, S Chauhan, G Yang, Q Worrall, BB Paré, G Kamatani, Y Hagemeijer, YP Verweij, N Siland, JE Kubo, M Smith, JD Van Wagoner, DR Bis, JC Perz, S Psaty, BM Ridker, PM Magnani, JW Harris, TB Launer, LJ Shoemaker, MB Padmanabhan, S Haessler, J Bartz, TM Waldenberger, M Lichtner, P Arendt, M Krieger, JE Kähönen, M Risch, L Mansur, AJ Peters, A Smith, BH Lind, L Scott, SA Lu, Y Bottinger, EB Hernesniemi, J Lindgren, CM Wong, JA Huang, J Eskola, M Morris, AP Ford, I Reiner, AP Delgado, G Chen, LY Chen, YI Sandhu, RK Li, M Boerwinkle, E Eisele, L Lannfelt, L Rost, N Anderson, CD Taylor, KD Campbell, A Magnusson, PK Porteous, D Hocking, LJ Vlachopoulou, E Pedersen, NL Nikus, K Orho-Melander, M Hamsten, A Heeringa, J Denny, JC Kriebel, J Darbar, D Newton-Cheh, C Shaffer, C Macfarlane, PW Heilmann-Heimbach, S Almgren, P Huang, PL Sotoodehnia, N Soliman, EZ Uitterlinden, AG Hofman, A Franco, OH Völker, U Jöckel, KH Sinner, MF Lin, HJ Guo, X METASTROKE Consortium of the ISGC, Neurology Working Group of the CHARGE Consortium, Dichgans, M Ingelsson, E Kooperberg, C Melander, O Loos, RJF Laurikka, J Conen, D Rosand, J van der Harst, P Lokki, ML Kathiresan, S Pereira, A Jukema, JW Hayward, C Rotter, JI März, W Lehtimäki, T Stricker, BH Chung, MK Felix, SB Gudnason, V Alonso, A Roden, DM Kääb, S Chasman, DI Heckbert, SR Benjamin, EJ Tanaka, T Lunetta, KL Lubitz, SA Ellinor, PT AFGen Consortium |
| author_sort | Christophersen, IE |
| collection | OXFORD |
| description | Atrial fibrillation affects more than 33 million people worldwide and increases the risk of stroke, heart failure, and death. Fourteen genetic loci have been associated with atrial fibrillation in European and Asian ancestry groups. To further define the genetic basis of atrial fibrillation, we performed large-scale, trans-ancestry meta-analyses of common and rare variant association studies. The genome-wide association studies (GWAS) included 17,931 individuals with atrial fibrillation and 115,142 referents; the exome-wide association studies (ExWAS) and rare variant association studies (RVAS) involved 22,346 cases and 132,086 referents. We identified 12 new genetic loci that exceeded genome-wide significance, implicating genes involved in cardiac electrical and structural remodeling. Our results nearly double the number of known genetic loci for atrial fibrillation, provide insights into the molecular basis of atrial fibrillation, and may facilitate the identification of new potential targets for drug discovery. |
| first_indexed | 2024-03-07T06:43:08Z |
| format | Journal article |
| id | oxford-uuid:f9f95006-10fd-44af-bbb8-1d85b6189c2b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:43:08Z |
| publishDate | 2017 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:f9f95006-10fd-44af-bbb8-1d85b6189c2b2022-03-27T13:02:41ZLarge-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillationJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:f9f95006-10fd-44af-bbb8-1d85b6189c2bEnglishSymplectic Elements at OxfordSpringer Nature2017Christophersen, IERienstra, MRoselli, CYin, XGeelhoed, BBarnard, JLin, HArking, DESmith, AVAlbert, CMChaffin, MTucker, NRLi, MKlarin, DBihlmeyer, NALow, SKWeeke, PEMüller-Nurasyid, MSmith, JGBrody, JANiemeijer, MNDörr, MTrompet, SHuffman, JGustafsson, SSchurmann, CKleber, MELyytikäinen, LPSeppälä, IMalik, RHorimoto, ARVRPerez, MSinisalo, JAeschbacher, SThériault, SYao, JRadmanesh, FWeiss, STeumer, AChoi, SHWeng, LCClauss, SDeo, RRader, DJShah, SHSun, AHopewell, JCDebette, SChauhan, GYang, QWorrall, BBParé, GKamatani, YHagemeijer, YPVerweij, NSiland, JEKubo, MSmith, JDVan Wagoner, DRBis, JCPerz, SPsaty, BMRidker, PMMagnani, JWHarris, TBLauner, LJShoemaker, MBPadmanabhan, SHaessler, JBartz, TMWaldenberger, MLichtner, PArendt, MKrieger, JEKähönen, MRisch, LMansur, AJPeters, ASmith, BHLind, LScott, SALu, YBottinger, EBHernesniemi, JLindgren, CMWong, JAHuang, JEskola, MMorris, APFord, IReiner, APDelgado, GChen, LYChen, YISandhu, RKLi, MBoerwinkle, EEisele, LLannfelt, LRost, NAnderson, CDTaylor, KDCampbell, AMagnusson, PKPorteous, DHocking, LJVlachopoulou, EPedersen, NLNikus, KOrho-Melander, MHamsten, AHeeringa, JDenny, JCKriebel, JDarbar, DNewton-Cheh, CShaffer, CMacfarlane, PWHeilmann-Heimbach, SAlmgren, PHuang, PLSotoodehnia, NSoliman, EZUitterlinden, AGHofman, AFranco, OHVölker, UJöckel, KHSinner, MFLin, HJGuo, XMETASTROKE Consortium of the ISGC,Neurology Working Group of the CHARGE Consortium,Dichgans, MIngelsson, EKooperberg, CMelander, OLoos, RJFLaurikka, JConen, DRosand, Jvan der Harst, PLokki, MLKathiresan, SPereira, AJukema, JWHayward, CRotter, JIMärz, WLehtimäki, TStricker, BHChung, MKFelix, SBGudnason, VAlonso, ARoden, DMKääb, SChasman, DIHeckbert, SRBenjamin, EJTanaka, TLunetta, KLLubitz, SAEllinor, PTAFGen ConsortiumAtrial fibrillation affects more than 33 million people worldwide and increases the risk of stroke, heart failure, and death. Fourteen genetic loci have been associated with atrial fibrillation in European and Asian ancestry groups. To further define the genetic basis of atrial fibrillation, we performed large-scale, trans-ancestry meta-analyses of common and rare variant association studies. The genome-wide association studies (GWAS) included 17,931 individuals with atrial fibrillation and 115,142 referents; the exome-wide association studies (ExWAS) and rare variant association studies (RVAS) involved 22,346 cases and 132,086 referents. We identified 12 new genetic loci that exceeded genome-wide significance, implicating genes involved in cardiac electrical and structural remodeling. Our results nearly double the number of known genetic loci for atrial fibrillation, provide insights into the molecular basis of atrial fibrillation, and may facilitate the identification of new potential targets for drug discovery. |
| spellingShingle | Christophersen, IE Rienstra, M Roselli, C Yin, X Geelhoed, B Barnard, J Lin, H Arking, DE Smith, AV Albert, CM Chaffin, M Tucker, NR Li, M Klarin, D Bihlmeyer, NA Low, SK Weeke, PE Müller-Nurasyid, M Smith, JG Brody, JA Niemeijer, MN Dörr, M Trompet, S Huffman, J Gustafsson, S Schurmann, C Kleber, ME Lyytikäinen, LP Seppälä, I Malik, R Horimoto, ARVR Perez, M Sinisalo, J Aeschbacher, S Thériault, S Yao, J Radmanesh, F Weiss, S Teumer, A Choi, SH Weng, LC Clauss, S Deo, R Rader, DJ Shah, SH Sun, A Hopewell, JC Debette, S Chauhan, G Yang, Q Worrall, BB Paré, G Kamatani, Y Hagemeijer, YP Verweij, N Siland, JE Kubo, M Smith, JD Van Wagoner, DR Bis, JC Perz, S Psaty, BM Ridker, PM Magnani, JW Harris, TB Launer, LJ Shoemaker, MB Padmanabhan, S Haessler, J Bartz, TM Waldenberger, M Lichtner, P Arendt, M Krieger, JE Kähönen, M Risch, L Mansur, AJ Peters, A Smith, BH Lind, L Scott, SA Lu, Y Bottinger, EB Hernesniemi, J Lindgren, CM Wong, JA Huang, J Eskola, M Morris, AP Ford, I Reiner, AP Delgado, G Chen, LY Chen, YI Sandhu, RK Li, M Boerwinkle, E Eisele, L Lannfelt, L Rost, N Anderson, CD Taylor, KD Campbell, A Magnusson, PK Porteous, D Hocking, LJ Vlachopoulou, E Pedersen, NL Nikus, K Orho-Melander, M Hamsten, A Heeringa, J Denny, JC Kriebel, J Darbar, D Newton-Cheh, C Shaffer, C Macfarlane, PW Heilmann-Heimbach, S Almgren, P Huang, PL Sotoodehnia, N Soliman, EZ Uitterlinden, AG Hofman, A Franco, OH Völker, U Jöckel, KH Sinner, MF Lin, HJ Guo, X METASTROKE Consortium of the ISGC, Neurology Working Group of the CHARGE Consortium, Dichgans, M Ingelsson, E Kooperberg, C Melander, O Loos, RJF Laurikka, J Conen, D Rosand, J van der Harst, P Lokki, ML Kathiresan, S Pereira, A Jukema, JW Hayward, C Rotter, JI März, W Lehtimäki, T Stricker, BH Chung, MK Felix, SB Gudnason, V Alonso, A Roden, DM Kääb, S Chasman, DI Heckbert, SR Benjamin, EJ Tanaka, T Lunetta, KL Lubitz, SA Ellinor, PT AFGen Consortium Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation |
| title | Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation |
| title_full | Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation |
| title_fullStr | Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation |
| title_full_unstemmed | Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation |
| title_short | Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation |
| title_sort | large scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation |
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largescaleanalysesofcommonandrarevariantsidentify12newlociassociatedwithatrialfibrillation AT haywardc largescaleanalysesofcommonandrarevariantsidentify12newlociassociatedwithatrialfibrillation AT rotterji largescaleanalysesofcommonandrarevariantsidentify12newlociassociatedwithatrialfibrillation AT marzw largescaleanalysesofcommonandrarevariantsidentify12newlociassociatedwithatrialfibrillation AT lehtimakit largescaleanalysesofcommonandrarevariantsidentify12newlociassociatedwithatrialfibrillation AT strickerbh largescaleanalysesofcommonandrarevariantsidentify12newlociassociatedwithatrialfibrillation AT chungmk largescaleanalysesofcommonandrarevariantsidentify12newlociassociatedwithatrialfibrillation AT felixsb largescaleanalysesofcommonandrarevariantsidentify12newlociassociatedwithatrialfibrillation AT gudnasonv largescaleanalysesofcommonandrarevariantsidentify12newlociassociatedwithatrialfibrillation AT alonsoa largescaleanalysesofcommonandrarevariantsidentify12newlociassociatedwithatrialfibrillation AT rodendm largescaleanalysesofcommonandrarevariantsidentify12newlociassociatedwithatrialfibrillation AT kaabs largescaleanalysesofcommonandrarevariantsidentify12newlociassociatedwithatrialfibrillation AT chasmandi largescaleanalysesofcommonandrarevariantsidentify12newlociassociatedwithatrialfibrillation AT heckbertsr largescaleanalysesofcommonandrarevariantsidentify12newlociassociatedwithatrialfibrillation AT benjaminej largescaleanalysesofcommonandrarevariantsidentify12newlociassociatedwithatrialfibrillation AT tanakat largescaleanalysesofcommonandrarevariantsidentify12newlociassociatedwithatrialfibrillation AT lunettakl largescaleanalysesofcommonandrarevariantsidentify12newlociassociatedwithatrialfibrillation AT lubitzsa largescaleanalysesofcommonandrarevariantsidentify12newlociassociatedwithatrialfibrillation AT ellinorpt largescaleanalysesofcommonandrarevariantsidentify12newlociassociatedwithatrialfibrillation AT afgenconsortium largescaleanalysesofcommonandrarevariantsidentify12newlociassociatedwithatrialfibrillation |