A compendium of sugar amino acids (SAA): scaffolds, peptide- and glyco-mimetics

Sugar amino acids (SAAs) are carbohydrate derivatives bearing both amino and carboxylic acid functionalities. SAAs are very versatile conformationally biased building blocks amenable to serve as glyco- or peptidomimetics. The stereochemical arrangement of the substituents of the sugar ring, its ring...

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Bibliographic Details
Main Authors: Risseeuw, M, Overhand, M, Fleet, G, Simone, M
Format: Journal article
Language:English
Published: 2007
Description
Summary:Sugar amino acids (SAAs) are carbohydrate derivatives bearing both amino and carboxylic acid functionalities. SAAs are very versatile conformationally biased building blocks amenable to serve as glyco- or peptidomimetics. The stereochemical arrangement of the substituents of the sugar ring, its ring-size as well as the presence of additional functional groups provides a plethora of possible combinations. In this overview the structures of oxygen heterocylic SAAs that have been reported thus far are provided, having 3, 4, 5, 6-membered rings as well as several bicyclic counterparts. © 2007 Elsevier Ltd. All rights reserved.