RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients
Rheumatoid arthritis (RA) is a chronic inflammatory disorder with poorly defined aetiology characterised by synovial inflammation with variable disease severity and drug responsiveness. To investigate the peripheral blood immune cell landscape of early, drug naive RA, we performed comprehensive clin...
| Κύριοι συγγραφείς: | , , , , , |
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| Άλλοι συγγραφείς: | |
| Μορφή: | Journal article |
| Γλώσσα: | English |
| Έκδοση: |
Nature Research
2022
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| _version_ | 1826307909107056640 |
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| author | Isaacs, JD Brockbank, S Pedersen, AW Taylor, P Buckley, C Coles, M |
| author2 | The RA-MAP Consortium |
| author_facet | The RA-MAP Consortium Isaacs, JD Brockbank, S Pedersen, AW Taylor, P Buckley, C Coles, M |
| author_sort | Isaacs, JD |
| collection | OXFORD |
| description | Rheumatoid arthritis (RA) is a chronic inflammatory disorder with poorly defined aetiology characterised by synovial inflammation with variable disease severity and drug responsiveness. To investigate the peripheral blood immune cell landscape of early, drug naive RA, we performed comprehensive clinical and molecular profiling of 267 RA patients and 52 healthy vaccine recipients for up to 18 months to establish a high quality sample biobank including plasma, serum, peripheral blood cells, urine, genomic DNA, RNA from whole blood, lymphocyte and monocyte subsets. We have performed extensive multi-omic immune phenotyping, including genomic, metabolomic, proteomic, transcriptomic and autoantibody profiling. We anticipate that these detailed clinical and molecular data will serve as a fundamental resource offering insights into immune-mediated disease pathogenesis, progression and therapeutic response, ultimately contributing to the development and application of targeted therapies for RA. |
| first_indexed | 2024-03-07T07:10:05Z |
| format | Journal article |
| id | oxford-uuid:fa346712-f7ac-48eb-8185-e47640921182 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:10:05Z |
| publishDate | 2022 |
| publisher | Nature Research |
| record_format | dspace |
| spelling | oxford-uuid:fa346712-f7ac-48eb-8185-e476409211822022-06-06T09:24:34ZRA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipientsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:fa346712-f7ac-48eb-8185-e47640921182EnglishSymplectic ElementsNature Research2022Isaacs, JDBrockbank, SPedersen, AWTaylor, PBuckley, CColes, MThe RA-MAP ConsortiumRheumatoid arthritis (RA) is a chronic inflammatory disorder with poorly defined aetiology characterised by synovial inflammation with variable disease severity and drug responsiveness. To investigate the peripheral blood immune cell landscape of early, drug naive RA, we performed comprehensive clinical and molecular profiling of 267 RA patients and 52 healthy vaccine recipients for up to 18 months to establish a high quality sample biobank including plasma, serum, peripheral blood cells, urine, genomic DNA, RNA from whole blood, lymphocyte and monocyte subsets. We have performed extensive multi-omic immune phenotyping, including genomic, metabolomic, proteomic, transcriptomic and autoantibody profiling. We anticipate that these detailed clinical and molecular data will serve as a fundamental resource offering insights into immune-mediated disease pathogenesis, progression and therapeutic response, ultimately contributing to the development and application of targeted therapies for RA. |
| spellingShingle | Isaacs, JD Brockbank, S Pedersen, AW Taylor, P Buckley, C Coles, M RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients |
| title | RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients |
| title_full | RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients |
| title_fullStr | RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients |
| title_full_unstemmed | RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients |
| title_short | RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients |
| title_sort | ra map molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients |
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