Characteristics and predictors of persistent symptoms post COVID-19 in children and young people: a large community cross-sectional study in England
<p><strong>Objective:</strong> To estimate the prevalence of, and associated risk factors for, persistent symptoms post COVID-19 among children aged 5-17 years in England.</p> <p><strong>Design:</strong> Serial cross-sectional study.</p> <p><...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
BMJ Publishing Group
2023
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| _version_ | 1826310259549929472 |
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| author | Atchison, C Whitaker, M Donnelly, CA Chadeau-Hyam, M Riley, S Darzi, A Ashby, D Barclay, WS Cooke, GS Elliott, P Ward, H |
| author_facet | Atchison, C Whitaker, M Donnelly, CA Chadeau-Hyam, M Riley, S Darzi, A Ashby, D Barclay, WS Cooke, GS Elliott, P Ward, H |
| author_sort | Atchison, C |
| collection | OXFORD |
| description | <p><strong>Objective:</strong> To estimate the prevalence of, and associated risk factors for, persistent symptoms post COVID-19 among children aged 5-17 years in England.</p>
<p><strong>Design:</strong> Serial cross-sectional study.</p>
<p><strong>Setting:</strong> Rounds 10-19 (March 2021 to March 2022) of the REACT-1 study (monthly cross-sectional surveys of random samples of the population in England).</p>
<p><strong>Study population:</strong> Children aged 5-17 years in the community.</p>
<p><strong>Predictors:</strong> Age, sex, ethnicity, presence of a pre-existing health condition, index of multiple deprivation, COVID-19 vaccination status, and dominant UK circulating SARS-CoV-2 variant at time
of symptom onset.</p>
<p><strong>Main outcome measures:</strong> Prevalence of persistent symptoms, reported as those lasting c; months post-COVID-19.</p>
<p><strong>Results:</strong> Overall, 4.4% (95% CI 3.7-5.1) of 3,173 5-11 year-olds and 13.3% (95% CI 12.5-14.1) of 6,886 12-17 year-olds with prior symptomatic infection reported at least one symptom lasting c;
months post-COVID-19, of whom 13.5% (95% CI 8.4-20.9) and 10.9% (95% CI 9.0-13.2),
respectively, reported their ability to carry out day-to-day activities was reduced “a lot” due to their
symptoms. The most common symptoms among participants with persistent symptoms were
persistent coughing (27.4%) and headaches (25.4%) in children aged 5-11 years and loss or change of
sense of smell (52.2%) and taste (40.7%) in participants aged 12-17 years. Higher age and having a
pre-existing health condition were associated with higher odds of reporting persistent symptoms.</p>
<p><strong>Conclusions:</strong> One in twenty-three 5-11 year-olds and one in eight 12-17 year-olds post-COVID-19 report persistent symptoms lasting c; months, of which one in nine report a large impact on
performing day-to-day activities.</p> |
| first_indexed | 2024-03-07T07:49:18Z |
| format | Journal article |
| id | oxford-uuid:fa389bbc-2745-4f44-931d-feac55b09182 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:49:18Z |
| publishDate | 2023 |
| publisher | BMJ Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:fa389bbc-2745-4f44-931d-feac55b091822023-06-22T09:28:24ZCharacteristics and predictors of persistent symptoms post COVID-19 in children and young people: a large community cross-sectional study in EnglandJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:fa389bbc-2745-4f44-931d-feac55b09182EnglishSymplectic ElementsBMJ Publishing Group2023Atchison, CWhitaker, MDonnelly, CAChadeau-Hyam, MRiley, SDarzi, AAshby, DBarclay, WSCooke, GSElliott, PWard, H<p><strong>Objective:</strong> To estimate the prevalence of, and associated risk factors for, persistent symptoms post COVID-19 among children aged 5-17 years in England.</p> <p><strong>Design:</strong> Serial cross-sectional study.</p> <p><strong>Setting:</strong> Rounds 10-19 (March 2021 to March 2022) of the REACT-1 study (monthly cross-sectional surveys of random samples of the population in England).</p> <p><strong>Study population:</strong> Children aged 5-17 years in the community.</p> <p><strong>Predictors:</strong> Age, sex, ethnicity, presence of a pre-existing health condition, index of multiple deprivation, COVID-19 vaccination status, and dominant UK circulating SARS-CoV-2 variant at time of symptom onset.</p> <p><strong>Main outcome measures:</strong> Prevalence of persistent symptoms, reported as those lasting c; months post-COVID-19.</p> <p><strong>Results:</strong> Overall, 4.4% (95% CI 3.7-5.1) of 3,173 5-11 year-olds and 13.3% (95% CI 12.5-14.1) of 6,886 12-17 year-olds with prior symptomatic infection reported at least one symptom lasting c; months post-COVID-19, of whom 13.5% (95% CI 8.4-20.9) and 10.9% (95% CI 9.0-13.2), respectively, reported their ability to carry out day-to-day activities was reduced “a lot” due to their symptoms. The most common symptoms among participants with persistent symptoms were persistent coughing (27.4%) and headaches (25.4%) in children aged 5-11 years and loss or change of sense of smell (52.2%) and taste (40.7%) in participants aged 12-17 years. Higher age and having a pre-existing health condition were associated with higher odds of reporting persistent symptoms.</p> <p><strong>Conclusions:</strong> One in twenty-three 5-11 year-olds and one in eight 12-17 year-olds post-COVID-19 report persistent symptoms lasting c; months, of which one in nine report a large impact on performing day-to-day activities.</p> |
| spellingShingle | Atchison, C Whitaker, M Donnelly, CA Chadeau-Hyam, M Riley, S Darzi, A Ashby, D Barclay, WS Cooke, GS Elliott, P Ward, H Characteristics and predictors of persistent symptoms post COVID-19 in children and young people: a large community cross-sectional study in England |
| title | Characteristics and predictors of persistent symptoms post COVID-19 in children and young people: a large community cross-sectional study in England |
| title_full | Characteristics and predictors of persistent symptoms post COVID-19 in children and young people: a large community cross-sectional study in England |
| title_fullStr | Characteristics and predictors of persistent symptoms post COVID-19 in children and young people: a large community cross-sectional study in England |
| title_full_unstemmed | Characteristics and predictors of persistent symptoms post COVID-19 in children and young people: a large community cross-sectional study in England |
| title_short | Characteristics and predictors of persistent symptoms post COVID-19 in children and young people: a large community cross-sectional study in England |
| title_sort | characteristics and predictors of persistent symptoms post covid 19 in children and young people a large community cross sectional study in england |
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