Binge-pattern alcohol consumption and genetic risk as determinants of alcohol-related liver disease
Alcohol-related liver disease (ARLD) represents a major public health burden. Identification of high-risk individuals would allow efficient targeting of public health interventions. Here, we show significant interactions between pattern of drinking, genetic predisposition (polygenic risk score, PRS)...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Springer Nature
2023
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| _version_ | 1797112975078719488 |
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| author | Ding, C Ng Fat, L Britton, A Im, PK Lin, K Topiwala, A Li, L Chen, Z Millwood, IY Bell, S Mehta, G |
| author_facet | Ding, C Ng Fat, L Britton, A Im, PK Lin, K Topiwala, A Li, L Chen, Z Millwood, IY Bell, S Mehta, G |
| author_sort | Ding, C |
| collection | OXFORD |
| description | Alcohol-related liver disease (ARLD) represents a major public health burden. Identification of high-risk individuals would allow efficient targeting of public health interventions. Here, we show significant interactions between pattern of drinking, genetic predisposition (polygenic risk score, PRS) and diabetes mellitus, and risk of incident ARLD, in 312,599 actively drinking adults in UK Biobank. Binge and heavy binge drinking significantly increase the risk of alcohol-related cirrhosis (ARC), with higher genetic predisposition further amplifying the risk. Further, we demonstrate a pronounced interaction between heavy binge drinking and high PRS, resulting in a relative excess risk due to interaction (RERI) of 6.07. Diabetes consistently elevates ARC risk across all drinking and PRS categories, and showed significant interaction with both binge patterns and genetic risk. Overall, we demonstrate synergistic effects of binge drinking, genetics, and diabetes on ARC, with potential to identify high-risk individuals for targeted interventions. |
| first_indexed | 2024-04-09T03:55:39Z |
| format | Journal article |
| id | oxford-uuid:fa6173ae-a491-4926-bc5b-a50d224519a5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-04-09T03:55:39Z |
| publishDate | 2023 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:fa6173ae-a491-4926-bc5b-a50d224519a52024-03-13T18:19:11ZBinge-pattern alcohol consumption and genetic risk as determinants of alcohol-related liver diseaseJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:fa6173ae-a491-4926-bc5b-a50d224519a5EnglishSymplectic ElementsSpringer Nature2023Ding, CNg Fat, LBritton, AIm, PKLin, KTopiwala, ALi, LChen, ZMillwood, IYBell, SMehta, GAlcohol-related liver disease (ARLD) represents a major public health burden. Identification of high-risk individuals would allow efficient targeting of public health interventions. Here, we show significant interactions between pattern of drinking, genetic predisposition (polygenic risk score, PRS) and diabetes mellitus, and risk of incident ARLD, in 312,599 actively drinking adults in UK Biobank. Binge and heavy binge drinking significantly increase the risk of alcohol-related cirrhosis (ARC), with higher genetic predisposition further amplifying the risk. Further, we demonstrate a pronounced interaction between heavy binge drinking and high PRS, resulting in a relative excess risk due to interaction (RERI) of 6.07. Diabetes consistently elevates ARC risk across all drinking and PRS categories, and showed significant interaction with both binge patterns and genetic risk. Overall, we demonstrate synergistic effects of binge drinking, genetics, and diabetes on ARC, with potential to identify high-risk individuals for targeted interventions. |
| spellingShingle | Ding, C Ng Fat, L Britton, A Im, PK Lin, K Topiwala, A Li, L Chen, Z Millwood, IY Bell, S Mehta, G Binge-pattern alcohol consumption and genetic risk as determinants of alcohol-related liver disease |
| title | Binge-pattern alcohol consumption and genetic risk as determinants of alcohol-related liver disease |
| title_full | Binge-pattern alcohol consumption and genetic risk as determinants of alcohol-related liver disease |
| title_fullStr | Binge-pattern alcohol consumption and genetic risk as determinants of alcohol-related liver disease |
| title_full_unstemmed | Binge-pattern alcohol consumption and genetic risk as determinants of alcohol-related liver disease |
| title_short | Binge-pattern alcohol consumption and genetic risk as determinants of alcohol-related liver disease |
| title_sort | binge pattern alcohol consumption and genetic risk as determinants of alcohol related liver disease |
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