Adrenaline stimulates glucagon secretion by Tpc2-dependent Ca2+ mobilization from acidic stores in pancreatic α-cells

Adrenaline stimulates glucagon secretion by Tpc2-dependent Ca2+ mobilization from acidic stores in pancreatic α-cells

Adrenaline is a powerful stimulus of glucagon secretion. It acts by activation of β-adrenergic receptors but the downstream mechanisms have only been partially elucidated. Here we have examined the effects of adrenaline in mouse and human α-cells by a combination of electrophysiology, imaging of Ca2...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Hamilton, A, Zhang, Q, Salehi, A, Willems, M, Knudsen, JG, Ringgaard, AK, Chapman, CE, Gonzalez-Alvarez, A, Surdo, NC, Zaccolo, M, Basco, D, Johnson, PRV, Ramracheya, RD, Rutter, GA, Galione, A, Rorsman, P, Tarasov, AI
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	American Diabetes Association 2018

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