Adrenaline stimulates glucagon secretion by Tpc2-dependent Ca2+ mobilization from acidic stores in pancreatic α-cells

Adrenaline stimulates glucagon secretion by Tpc2-dependent Ca2+ mobilization from acidic stores in pancreatic α-cells

Adrenaline is a powerful stimulus of glucagon secretion. It acts by activation of β-adrenergic receptors but the downstream mechanisms have only been partially elucidated. Here we have examined the effects of adrenaline in mouse and human α-cells by a combination of electrophysiology, imaging of Ca2...

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Chi tiết về thư mục
Những tác giả chính:	Hamilton, A, Zhang, Q, Salehi, A, Willems, M, Knudsen, JG, Ringgaard, AK, Chapman, CE, Gonzalez-Alvarez, A, Surdo, NC, Zaccolo, M, Basco, D, Johnson, PRV, Ramracheya, RD, Rutter, GA, Galione, A, Rorsman, P, Tarasov, AI
Định dạng:	Journal article
Ngôn ngữ:	English
Được phát hành:	American Diabetes Association 2018

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