HIV-1 Nef down-regulates the hemochromatosis protein HFE, manipulating cellular iron homeostasis.

HIV-1 Nef down-regulates the hemochromatosis protein HFE, manipulating cellular iron homeostasis.

The multifunctional Nef protein of HIV-1 is important for the progression to AIDS. One action of Nef is to down-regulate surface MHC I molecules, helping infected cells to evade immunity. We found that Nef also down-regulates the macrophage-expressed MHC 1b protein HFE, which regulates iron homeosta...

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Dettagli Bibliografici
Autori principali:	Drakesmith, H, Chen, N, Ledermann, H, Screaton, G, Townsend, A, Xu, X
Natura:	Journal article
Lingua:	English
Pubblicazione:	2005

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