Structure and chromosomal location of mouse and human CD52 genes.
Human CD52 (CAMPATH-1 antigen) is an abundant surface molecule on lymphocytes and a favoured target for lymphoma therapy and immunosuppression. It comprises a small glycosylphosphatidylinositol (GPI) anchored peptide to which a large carbohydrate moiety is attached. Structurally similar proteins inc...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1999
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| _version_ | 1797105226749050880 |
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| author | Tone, M Nolan, K Walsh, L Tone, Y Thompson, SA Waldmann, H |
| author_facet | Tone, M Nolan, K Walsh, L Tone, Y Thompson, SA Waldmann, H |
| author_sort | Tone, M |
| collection | OXFORD |
| description | Human CD52 (CAMPATH-1 antigen) is an abundant surface molecule on lymphocytes and a favoured target for lymphoma therapy and immunosuppression. It comprises a small glycosylphosphatidylinositol (GPI) anchored peptide to which a large carbohydrate moiety is attached. Structurally similar proteins include the proposed mouse homologue, B7 antigen (B7-Ag; not to be confused with the CD28 ligand), and human and mouse CD24. Sequence similarities between CD52 and B7-Ag precursors are concentrated over the signal peptides and the sequences cleaved during GPI attachment. While the short mature peptides are not apparently homologous, the N-linked glycosylation site is retained in both. We describe similarities in exon-intron organisation, syntenic chromosome positions (human CD52, 1p36; mouse B7-Ag, chromosome 4, between Dsil and D4Nds16) and sequence homology in the promoter regions which strongly suggests that B7-Ag is the mouse homologue of CD52. The structure of these genes is also similar to that of mouse CD24, suggesting a common ancestor. Promoter activities and transcription start sites were also analysed. These results suggest that human CD52 and mouse B7-Ag gene expressions are controlled by TATA-less promoters. |
| first_indexed | 2024-03-07T06:44:28Z |
| format | Journal article |
| id | oxford-uuid:fa647784-40c9-4005-8faa-922728764dba |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:44:28Z |
| publishDate | 1999 |
| record_format | dspace |
| spelling | oxford-uuid:fa647784-40c9-4005-8faa-922728764dba2022-03-27T13:05:31ZStructure and chromosomal location of mouse and human CD52 genes.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:fa647784-40c9-4005-8faa-922728764dbaEnglishSymplectic Elements at Oxford1999Tone, MNolan, KWalsh, LTone, YThompson, SAWaldmann, HHuman CD52 (CAMPATH-1 antigen) is an abundant surface molecule on lymphocytes and a favoured target for lymphoma therapy and immunosuppression. It comprises a small glycosylphosphatidylinositol (GPI) anchored peptide to which a large carbohydrate moiety is attached. Structurally similar proteins include the proposed mouse homologue, B7 antigen (B7-Ag; not to be confused with the CD28 ligand), and human and mouse CD24. Sequence similarities between CD52 and B7-Ag precursors are concentrated over the signal peptides and the sequences cleaved during GPI attachment. While the short mature peptides are not apparently homologous, the N-linked glycosylation site is retained in both. We describe similarities in exon-intron organisation, syntenic chromosome positions (human CD52, 1p36; mouse B7-Ag, chromosome 4, between Dsil and D4Nds16) and sequence homology in the promoter regions which strongly suggests that B7-Ag is the mouse homologue of CD52. The structure of these genes is also similar to that of mouse CD24, suggesting a common ancestor. Promoter activities and transcription start sites were also analysed. These results suggest that human CD52 and mouse B7-Ag gene expressions are controlled by TATA-less promoters. |
| spellingShingle | Tone, M Nolan, K Walsh, L Tone, Y Thompson, SA Waldmann, H Structure and chromosomal location of mouse and human CD52 genes. |
| title | Structure and chromosomal location of mouse and human CD52 genes. |
| title_full | Structure and chromosomal location of mouse and human CD52 genes. |
| title_fullStr | Structure and chromosomal location of mouse and human CD52 genes. |
| title_full_unstemmed | Structure and chromosomal location of mouse and human CD52 genes. |
| title_short | Structure and chromosomal location of mouse and human CD52 genes. |
| title_sort | structure and chromosomal location of mouse and human cd52 genes |
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