Improved cell-penetrating peptide-PNA conjugates for splicing redirection in HeLa cells and exon skipping in mdx mouse muscle.

Improved cell-penetrating peptide-PNA conjugates for splicing redirection in HeLa cells and exon skipping in mdx mouse muscle.

Steric blocking peptide nucleic acid (PNA) oligonucleotides have been used increasingly for redirecting RNA splicing particularly in therapeutic applications such as Duchenne muscular dystrophy (DMD). Covalent attachment of a cell-penetrating peptide helps to improve cell delivery of PNA. We have us...

書誌詳細
主要な著者:	Ivanova, G, Arzumanov, A, Abes, R, Yin, H, Wood, M, Lebleu, B, Gait, M
フォーマット:	Journal article
言語:	English
出版事項:	2008

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